Products

Anti-CD30 Immunocytokine, scFv (HRS3)-scIL12 (ACFP-SH127)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD30 scFv to scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD30 as well as the biological activity of IL12. The anti-CD30-IL12 antibody-cytokine fusion protein is composed of a CD30 binding domain (HRS3-scFv) linked to p40-p35 murine single chain IL12. After binding to CD30+ H/RS cells, the fusion protein stimulates T cells to secrete IFN-γ, a predominant Th1 cytokine, and induces NK cells to lyse CD30+ cells with high efficiency. These properties make the HRS3-scFv-IL12 fusion protein suitable for the specific immunotherapy of Hodgkin's lymphoma. This immunocytokine was designed for treating CD30-positive lymphoma.      

Specifications
Target
CD30
Molecule Class
scFv-IL12
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
HRS3
Related Disease
CD30-positive lymphoma
Cytokines 1
scIL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily; member 8; CD30; Ki-1; D1S166E; tumor necrosis factor receptor superfamily member 8; Ki-1 antigen
Entrez Gene ID
943
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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