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anti-CD33 immunotoxin M195 (IgG)-Gel (AGTO-L050G)

This immunotoxin was achieved by conjugating/fusing the Anti-CD33 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to leukemia cells. Once bind, the toxin enters cells by receptor-mediated endocytosis, then gelonin inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treatment of leukemia.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
M195
Molecule Class
L kappa; IgG1-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30, 000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Leukemia
Target
Alternative Names
CD33; CD33 molecule; p67; SIGLEC3; SIGLEC-3; myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67)
Entrez Gene ID
945
UniProt ID
P20138

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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