Products

Anti-CD38 immunotoxin IB4 (IgG)-Gel (AGTO-G009G)

This immunotoxin was achieved by conjugating/fusing the Anti-CD38 monoclonal antibody to gelonin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD38+ cells. Once bind, the toxin enters cells by receptor-mediated endocytosis. Then, gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes. It was designed for treating Non Hodgkin lymphoma (NHL).      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
IB4
Molecule Class
IgG-Gel
Toxin Description
Gelonin is a glycoprotein (M.W. approximately 29-30,000 Kd) purified from the seeds of Gelonium multiforum and belongs to a class of potent ribosomal-inactivating plant toxins. Gelonin, like abrin and ricin, inhibits protein synthesis by damaging the 60S subunit of mammalian ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Non Hodgkin Lymphoma (NHL)
Target
Alternative Names
CD38; CD38 molecule; T10; ADPRC 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase
Entrez Gene ID
952
UniProt ID
P28907

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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