Products

Anti-CD38 immunotoxin IB4 (IgG)-Sap (AGTO-G009S)

This immunotoxin was achieved by conjugating/fusing the Anti-CD38 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD38+ cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Non Hodgkin lymphoma (NHL).      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
IB4
Molecule Class
IgG-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Non Hodgkin Lymphoma (NHL)
Target
Alternative Names
CD38; CD38 molecule; T10; ADPRC 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; CD38 antigen (p45); NAD(+) nucleosidase
Entrez Gene ID
952
UniProt ID
P28907

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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