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anti-CD3E immunotoxin UCHT1 (IgG)-DT (AGTO-L049D)

This immunotoxin was achieved by conjugating/fusing the Anti-CD3E monoclonal antibody to Diphtheriatoxin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to cells which carry a CD3 epitope. Once bind, the toxin enters cells by receptor-mediated endocytosis, then Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme; -II binding and elongation factor into the eukaryotic cell; the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs; thereby preventing protein synthesis and causes cell death. It was designed for treatment of T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
UCHT1
Molecule Class
L kappa; IgG1-DT
Toxin Description
Diphtheria toxin (Diphtheriatoxin, DT) is a cell toxin produced by diphtheria, is a protein toxin most commonly used in the construction of recombinant immunotoxin. Before the N-terminal 193 amino acids corresponding to the catalytic domain of DT enzyme, -II binding and elongation factor into the eukaryotic cell, the cell can catalyze specific elongation factor EF2 amide His699 of diphtheria ADP2 ribosylation occurs, thereby preventing protein synthesis and causes cell death.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias and lymphomas, graft-versus-host diseases, and autoimmune diseases
Target
Alternative Names
CD3E; CD3e molecule, epsilon (CD3-TCR complex); T3E; TCRE; IMD18; T-cell surface glycoprotein CD3 epsilon chain; CD3-epsilon; T-cell surface antigen T3/Leu-4 epsilon chain
Entrez Gene ID
916
UniProt ID
P07766

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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