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Anti-CD4 Immunocytokine, IL2-IgG (OKT4) (ACFP-SH122)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD4 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD4 as well as the biological activity of IL2. IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein supported mainly proliferation and lymphokine-activated killer cell activity. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of both IL2-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.      

Specifications
Target
CD4
Molecule Class
IL2-IgG
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
OKT4
Related Disease
Tumor
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD4; CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Antigen; CD4mut; CD4 Receptor; CD4 Antigen (P55)
Entrez Gene ID
920
UniProt ID
B4DT49

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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