Anti-CD4 Antibody-Cytokine Fusion Protein, IL2-IgG (OKT4) (CAT#: ACFP-SH122)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD4 IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD4 as well as the biological activity of IL2. IL2-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein supported mainly proliferation and lymphokine-activated killer cell activity. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of both IL2-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11/if_selected.jpg
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Figure 2 RNA cell line category: Group enriched (HEL, HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000010610-CD4
Specifications
- Target
- CD4
- Molecule Class
- IL2-IgG
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- OKT4
- Related Disease
- Tumor
- Cytokine 1
- IL2
- Cytokines 1 Description
- Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
- Cytokine 1 Species
- Human
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- CD4; CD4 Molecule; T-Cell Surface Antigen T4/Leu-3; T-Cell Surface Glycoprotein CD4; CD4 Antigen; CD4mut; CD4 Receptor; CD4 Antigen (P55)
- Gene ID
- 920
- UniProt ID
- B4DT49
Related Resources
Primary Immunodeficiency
Downloads
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See other products for "Clone OKT4"
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Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039 | Anti-Human CD4 Recombinant Antibody (Zanolimumab) | Neut, ELISA, IF, IP, FuncS, FC, IHC | IgG1 - kappa |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-164 | Anti-Human CD4 Recombinant Antibody (Priliximab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
| TAB-165LC-S(P) | Monkey Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-165LC-S(P)) | FC, SPR, ELISA | Monkey scFv |
| TAB-167LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (cM-T412) | ELISA | Chimeric antibody (mouse/human) |
| TAB-170LC-S(P) | Rat Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-170LC-S(P)) | ELISA, SPR | Rat scFv |
| TAB-170LC-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (TAB-170LC-F(E)) | ELISA, SPR | Chimeric antibody (rat/human) |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G078E | Anti-CD4 immunotoxin M-T151 (IgG)-PE | Cytotoxicity assay, Function study | |
| AGTO-G078R | Anti-CD4 immunotoxin M-T151 (IgG)-RTA | Cytotoxicity assay, Function study |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-423 | Human Anti-CD4 Recombinant Antibody (clone 576); Fab Fragment | WB, ELISA, FuncS | Human Fab |
| PFBL-424 | Human Anti-CD4 Recombinant Antibody (clone Hu5A8); Fab Fragment | Block, Neut | Human Fab |
| HPAB-0135CQ-F(E) | Human Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-0135CQ-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0136CQ-F(E) | Mouse Anti-CD4 Recombinant Antibody; Fab Fragment (HPAB-0136CQ-F(E)) | ELISA, FuncS | Mouse Fab |
| HPAB-0137CQ-F(E) | Mouse Anti-CD4 Recombinant Antibody (clone RIB 5/2); Fab Fragment | IHC, FC | Mouse Fab |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-160LC | Anti-Human CD4 Recombinant Antibody (OKT4A) | ELISA, WB | |
| TAB-166LC | Anti-Human CD4 Recombinant Antibody (M-T412) | ELISA, Inhib | |
| TAB-169LC | Rat Anti-CD4 Recombinant Antibody (TAB-169LC) | ELISA, FC, SPR | Rat IgG |
| TAB-173LC | Anti-Human CD4 Recombinant Antibody (IgA F425-Alg8) | ELISA, Inhib | |
| TAB-174LC | Mouse Anti-CD4 Recombinant Antibody (TAB-174LC) | ELISA, FC, IHC, Neut, FuncS | Mouse IgG1 |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-161LC | Anti-Human CD4 Recombinant Antibody (gOKT4A-4) | ELISA | Humanized antibody |
| TAB-168LC | Anti-Human CD4 Recombinant Antibody (TRX1) | ELISA | Humanized antibody |
| TAB-168LC-S(P) | Anti-Human CD4 Recombinant Antibody scFv Fragment (TRX1) | ELISA | Humanized antibody |
| TAB-171LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-171LC-S(P)) | ELISA, SPR | Humanized scFv |
| TAB-172LC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (TAB-172LC-S(P)) | ELISA | Human scFv |
Fab Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-025LC | Recombinant Anti-Human CD4 Antibody (Fab glycosylation) | ELISA | Humanized antibody |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-351CQ | Mouse Anti-CD4 Recombinant Antibody (clone 10C12) | ELISA, WB, IF, Block | Mouse IgG1 |
| NEUT-352CQ | Mouse Anti-CD4 Recombinant Antibody (clone 13B8.2) | Block, ELISA, FC, IHC-Fr, WB | Mouse IgG1, κ |
| NEUT-355CQ | Mouse Anti-CD4 Recombinant Antibody (clone RPA-T4) | FC, CyTOF, Block, IHC | Mouse IgG1, κ |
| NEUT-357CQ | Rat Anti-CD4 Recombinant Antibody (clone MAB0810) | Block, Depletion, Stim | Rat IgG2b |
| NEUT-358CQ | Rat Anti-CD4 Recombinant Antibody (clone RM4-5) | FC, CyTOF, Depletion, Block, IHC | Rat IgG2a, κ |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-353CQ | Mouse Anti-CD4 Recombinant Antibody (clone CBL976) | FC, Neut, IF, IHC | Mouse IgG1, κ |
| NEUT-354CQ | Recombinant Mouse Anti-CD4 Antibody (CT-4) | Neut, FC, IHC, IHC-Fr, IHC-P, IP | IgG1, κ |
| NEUT-356CQ | Mouse Anti-CD4 Recombinant Antibody (clone 3-4F4) | Neut, FC, IHC, IHC-Fr, IP, ICC | Mouse IgG1, κ |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0560 | Hi-Affi™ Rabbit Anti-CD4 Recombinant Antibody (clone DS560AB) | IHC-P | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0007-CN | Mouse Anti-CD4 Recombinant Antibody (clone CT4) | FC | Mouse IgG |
| FAMAB-0008-CN | Mouse Anti-CD4 Recombinant Antibody (clone EP96) | FC | Mouse IgG |
| FN-244CQ | Mouse Anti-CD4 Recombinant Antibody (clone OKT4 (OKT-4)) | FC, FuncS, IP | Mouse IgG2b, κ |
| HPAB-2059LY | Mouse Anti-CD4 Recombinant Antibody (HPAB-2059LY) | FC | Mouse IgG |
| HPAB-0957WJ | Human Anti-CD4 Recombinant Antibody (clone 4-91) | ELISA | Human IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-039 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Zanolimumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| AFC-TAB-164 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Priliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-260 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Tregalizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-171 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Keliximab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-107 | Afuco™ Anti-CD4 ADCC Recombinant Antibody (Cedelizumab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0049-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0049-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
| HPAB-J0050-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0050-YC-S(P)) | ELISA, FC, ADCC, CDC | Rat scFv |
| HPAB-J0051-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0051-YC-S(P)) | ELISA, FC | Humanized (rat/human) scFv |
| HPAB-J0052-YC-S(P) | Human Anti-CD4 Recombinant Antibody; scFv Fragment (HPAB-J0052-YC-S(P)) | ELISA, FC | Humanized (rat/human) scFv |
| HPAB-2112-FY-S(P) | Mouse Anti-CD4 Recombinant Antibody (clone MT15.1); scFv Fragment | Inhib | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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