Recombinant monoclonal antibody to CD44. chPTA-4621 is a chimeric antibody (mouse/human) that can be potentially used in the treatment of head and neck squamous cell carcinoma (HNSCC).
Figure 1 demonstrates the effect of a chimeric PTA-4621 on mouse body weight in an established human T.Tn HNSCC model.
Data points represent the mean +/- SEM.
Figure 2 demonstrates the effect of humanized PTA-4621 on tumor growth in an established SCC-15 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 3 demonstrates the effect of humanized PTA-4621 on tumor growth in an established Detroit 562 HNSCC model.
The vertical dashed lines indicate the period during which the antibody was intraperitoneally administered. Data points represent the mean +/- SEM.
Figure 4 demonstrates the effect of humanized PTA-4621 on relative tumor volume in an established CAL 27 HNSCC model.
Figure 5 demonstrates the effect of humanized PTA-4621 on tumor growth in an established CAL 27 HNSCC xenograft model. Tumor volume is presented as the group mean + minus SEM. Vertical dashed lines indicate the first and last day of dosing.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-727 | Anti-CD44 Recombinant Antibody (Bivatuzumab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 |
TAB-236LC | Anti-Human CD44 Recombinant Antibody (huPTA-4621) | FuncS | Humanized antibody |
TAB-236LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (huPTA-4621) | FC | Humanized antibody |
TAB-236LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (huPTA-4621) | FC | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-226LC-S(P) | Human Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-226LC-S(P)) | WB, ELISA | Human scFv |
TAB-227LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (1A9.A6.B9) | FC, ELISA | Human antibody |
TAB-228LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (2D1.A3.D12) | FC, ELISA | Human antibody |
TAB-229LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (14G9.B8.B4) | FC, ELISA | Human antibody |
TAB-230LC-S(P) | Anti-Human CD44 Recombinant Antibody scFv Fragment (10C8.2.3) | FC, ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-231LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-231LC-S(P)) | ELISA | Mouse scFv |
TAB-232LC-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (TAB-232LC-S(P)) | ELISA | Mouse scFv |
TAB-231LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-231LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-232LC-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (TAB-232LC-F(E)) | ELISA | Chimeric (mouse/human) Fab |
TAB-235LC-F(E) | Anti-Human CD44 Recombinant Antibody Fab Fragment (chPTA-4621) | FC | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
BRD-0101MZ | Chicken Anti-CD44 Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-378CQ | Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) | FC, IF, Inhib, IP, WB | Rat IgG2b |
NEUT-381CQ | Human Anti-CD44 Recombinant Antibody (clone Hermes-3) | ELISA, FC, IF, IHC, IP, Neut, WB | Human IgG1, κ |
NEUT-382CQ | Rat Anti-CD44 Recombinant Antibody (clone IM7) | Block | Rat IgG2b |
NEUT-383CQ | Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC | Block, FC, IP, WB, FuncS | Rat IgG1, κ |
NEUT-384CQ | Rat Anti-CD44 Recombinant Antibody (clone KM81) | IF, IHC-P, FC, Block | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-379CQ | Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) | WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC | Mouse IgG2a |
NEUT-380CQ | Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) | WB, Neut, ELISA, FC, IF, IHC, IP | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0563 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) | FC, IF, IHC-Fr, IHC-P, WB | Rabbit IgG |
MOR-4548 | Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) | IF, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0019-CN | Mouse Anti-CD44 Recombinant Antibody (clone AV6) | FC | Mouse IgG |
HPAB-0154-FY | Human Anti-CD44 Recombinant Antibody (clone (hu)ARH460-16-2 variant HV2/KV1) | Inhib, WB | Humanized IgG1 |
HPAB-0746-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0746-FY) | ELISA | Human IgG |
HPAB-0747-FY | Human Anti-CD44 Recombinant Antibody (HPAB-0747-FY) | ELISA | Human IgG |
HPAB-1173WJ | Human Anti-CD44 Recombinant Antibody (HPAB-1173WJ) | ELISA, Inhib | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0019-CN-S(P) | Mouse Anti-CD44 Recombinant Antibody (clone AV6); scFv Fragment | FC | Mouse scFv |
HPAB-N0328-YC-S(P) | Rat Anti-CD44 Recombinant Antibody (clone 9A4); scFv Fragment | WB, ELISA, IHC-P, IHC-Fr | Rat scFv |
HPAB-0746-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0746-FY-F(E)) | ELISA | Human Fab |
HPAB-0747-FY-F(E) | Human Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-0747-FY-F(E)) | ELISA | Human Fab |
HPAB-1055-FY-F(E) | Mouse Anti-CD44 Recombinant Antibody; Fab Fragment (HPAB-1055-FY-F(E)) | IHC, Inhib, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-727 | Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0563-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 1A9); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0564-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 2D1); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0565-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 14G9); Fab Fragment | ELISA, FC | Human Fab |
HPAB-0566-WJ-F(E) | Human Anti-CD44 Recombinant Antibody (clone 10C8); Fab Fragment | ELISA, FC | Human Fab |
HPAB-1055-FY-S(P) | Mouse Anti-CD44 Recombinant Antibody; scFv Fragment (HPAB-1055-FY-S(P)) | IHC, Inhib, FC | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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