Anti-CD44 Recombinant Antibody (Bivatuzumab) (CAT#: TAB-727)

Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6. It has been chemically linked to various radioisotopes for use in radiotherapy for, e.g. inoperable recurrent or metastatic head and neck cancer. It has also been linked to a cytotoxic drug mertansine to form bivatuzumab mertansine.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 2 Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA.

Figure 2 Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA.

Average blood clearance curves of 186Re-BIWA 4 as assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A) or by 186Re radioactivity measurement in serum (B). Individual data points are depicted after administration of 50 mg of BIWA 4 labeled with 31.9–108.2 mCi of 186Re to 20 HNSCC patients.

Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.

ELISA

Figure 3 Blood clearance curves of 186Re-BIWA 4 for patients who received the conjugate twice.

Figure 3 Blood clearance curves of 186Re-BIWA 4 for patients who received the conjugate twice.

Blood clearance was assessed by ELISA for measuring immunoreactive BIWA 4 in plasma (A–C) or by 186Re activity measurement in serum (D–F), after the first (▵) and second (○) administration of 186Re-BIWA 4 to patients 11 (A and D), 12 (B and E), and 14 (C and F).

Börjesson, P. K., Postema, E. J., Roos, J. C., Colnot, D. R., Marres, H. A., Van Schie, M. H.,... & Van Dongen, G. A. (2003). Phase I therapy study with 186Re-labeled humanized monoclonal antibody BIWA 4 (bivatuzumab) in patients with head and neck squamous cell carcinoma. Clinical Cancer Research, 9(10), 3961s-3972s.


Specifications

  • Immunogen
  • The details of the immunogen for this antibody are not available.
  • Host Species
  • Mouse
  • Derivation
  • Humanized (from mouse)
  • Type
  • IgG1
  • Species Reactivity
  • Human
  • Applications
  • ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ
  • CAS
  • 214599-60-1
  • Generic Name
  • bivatuzumab
  • Related Disease
  • Squamous cancers

Product Property

  • Purity
  • Purity >95% by SDS-PAGE.
  • Storage
  • At -20°C for one year.

Applications

  • Application Notes
  • The CD44 antibody has been reported in applications of ELISA, FC, IP, FuncS, IF, Neut, ICC, Activ.

Target

  • Alternative Names
  • bivatuzumab;214599-60-1;BIWA 4;CD44;CD44 molecule (Indian blood group);CD44 antigen (homing function and Indian blood group system) , MDU2, MDU3, MIC4;CD44 antigen;CD44R;chondroitin sulfate proteoglycan 8;CSPG8;HCELL;hematopoietic cell E and L selectin li

Related Resources

  • Biosimilar Overview
Please refer to Bivatuzumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Bivatuzumab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Bivatuzumab"

Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized (from mouse) antibody expressed in CHO binding to human CD44. Bivatuzumab is a humanized monoclonal antibody against CD44 v6.

See other products for "CD44"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0101MZ Chicken Anti-CD44 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-378CQ Rat Anti-CD44 Recombinant Antibody (clone 1M7.8.1) FC, IF, Inhib, IP, WB Rat IgG2b
NEUT-381CQ Human Anti-CD44 Recombinant Antibody (clone Hermes-3) ELISA, FC, IF, IHC, IP, Neut, WB Human IgG1, κ
NEUT-382CQ Rat Anti-CD44 Recombinant Antibody (clone IM7) Block Rat IgG2b
NEUT-383CQ Rat Anti-CD44 Recombinant Antibody (clone KM201), FITC Block, FC, IP, WB, FuncS Rat IgG1, κ
NEUT-384CQ Rat Anti-CD44 Recombinant Antibody (clone KM81) IF, IHC-P, FC, Block Rat IgG2a

Neutralizing Antibody

CAT Product Name Application Type
NEUT-379CQ Mouse Anti-CD44 Recombinant Antibody (clone F10-44-2) WB, Neut, FC, IHC, IHC-Fr, IHC-P, IP, ICC Mouse IgG2a
NEUT-380CQ Rat Anti-CD44 Recombinant Antibody (clone Hermes-1) WB, Neut, ELISA, FC, IF, IHC, IP Rat IgG2a

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0563 Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone DS563AB) FC, IF, IHC-Fr, IHC-P, WB Rabbit IgG
MOR-4548 Hi-Affi™ Rabbit Anti-CD44 Recombinant Antibody (clone TH58DS) IF, ICC, FC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-727 Afuco™ Anti-CD44 ADCC Recombinant Antibody (Bivatuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-727. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare