Products

Anti-CD46 Therapeutic Antibody (SC1.149) (TAB-269LC)

Recombinant monoclonal antibody to CD46. SC1.149 is a mouse monoclonal antibody that can be potentially used in the treatment of hyperproliferative disorder.      

Specifications
Immunogen
Synthetic CD46 peptide
Host
Mouse
Specificity
Human
Clone
SC1.149
Applications
FC, ELISA
Related Disease
Hyperproliferative disorder
Target
Alternative Names
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.
Entrez Gene ID
4179
UniProt ID
P15529

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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