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anti-CD5 immunotoxin H65 (scFv)-PT (AGTO-L053T)

This immunotoxin was achieved by conjugating/fusing the Anti-CD5 scFv to Pyrularia thionin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to T cells which express the CD5 antigen and the toxin enters cells by receptor-mediated endocytosis. Then PT causes a number of damaging cellular responses including hemolysis of erythrocytes; depolarization of the cellular membrane; activation of a calcium ion channel; and activation of endogenous phospholipase A2 enzyme. It was designed for treatment of T cell leukemias or lymphomas, graft-versus-host diseases, and autoimmune diseases.      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
H65
Molecule Class
scFv-PT
Toxin Description
PT is a small, highly basic and stable, 47 amino acid residue peptide. PT belongs to a family of peptides which, with the exception of crambin, exhibit some degree of toxicity towards animals and cultured cells including yeast, fungi, bacteria, and mammalian cells. PT, however, does not display any toxicity towards bacteria. At moderate concentrations it is toxic to cancer cells in culture and at higher concentrations it is toxic to mice. PT causes a number of damaging cellular responses including hemolysis of erythrocytes, depolarization of the cellular membrane, activation of a calcium ion channel, and activation of endogenous phospholipase A2 enzyme.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
T cell leukemias or lymphomas, graft- versus-host diseases, and autoimmune diseases
Target
Alternative Names
CD5; CD5 molecule; T1; LEU1; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; T cell leukemias
Entrez Gene ID
921
UniProt ID
P06127

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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