Recombinant Rat Antibody (CAMPATH-1G) Fab Fragment is specific to CD52.
Figure 1 Scattergrams of cells stained with 7-AAD show specific cell death induced by Campath-1G.
(A) Purified DCs cultured with Campath-1G. (B) Purified DC culture with control antibody Campath-1G.
Klangsinsirikul, P., Carter, G. I., Byrne, J. L., Hale, G., & Russell, N. H. (2002). Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood, 99(7), 2586-2591.
Figure 2 Depletion of DCs by in vivo Campath.
Circulating host DCs were depleted 24 hours after the first dose of Campath antibody. In this case the number of DCs fell from 19.19 × 10⁶/L (A) to 0.80 × 10⁶/mL (B).
Klangsinsirikul, P., Carter, G. I., Byrne, J. L., Hale, G., & Russell, N. H. (2002). Campath-1G causes rapid depletion of circulating host dendritic cells (DCs) before allogeneic transplantation but does not delay donor DC reconstitution. Blood, 99(7), 2586-2591.
Figure 3 Log depletion of T and B cell subsets following purging of standard density PBSC with CAMPATH-1H, -1M or -1G
Williams, R. J., Clarke, E., Blair, A., Evely, R., Hale, G., Waldmann, H., ... & Pamphilon, D. H. (2000). Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G. Cytotherapy, 2(1), 5-14.
Figure 4 Recovery of CD34+ cells and committed progenitor cells following treatment with CAMPATH-1H(a), -1M(b) and -1G (c) on PBSC (≤50×10⁶ /mL).
*p<0.05 for CAMPATH-11H compared with CAMPATH-11M. † p <0.05 for result at one MAb concentration compared with lower concentration
Williams, R. J., Clarke, E., Blair, A., Evely, R., Hale, G., Waldmann, H., ... & Pamphilon, D. H. (2000). Impact on T-cell depletion and CD34+ cell recovery using humanised CD52 monoclonal antibody (CAMPATH-1H) in BM and PSBC collections; comparison with CAMPATH-1M and CAMPATH-1G. Cytotherapy, 2(1), 5-14.
Figure 5 Binding of CDS2 antibodies to the native peptide
Hale, G. (1995). Synthetic peptide mimotope of the CAMPATH-1 (CD52) antigen, a small glycosylphosphatidylinositol-anchored glycoprotein. Immunotechnology, 1(3-4), 175-187.
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1223z | Mouse Anti-CD52 Recombinant Antibody (clone 20C9) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1, κ |
PABC-021 | Rat Anti-CD52 Recombinant Antibody (clone CAMPATH-1G) | WB, IHC, IF, FuncS | Rat IgG2b |
MOB-0508CT | Mouse Anti-CD52 Recombinant Antibody (clone IJ297) | FC, IHC-P | Mouse IgG2b |
FAMAB-0045YC | Rat Anti-CD52 Recombinant Antibody (clone YTH 34.5HL) | ELISA | Rat IgG2a, κ |
HPAB-0387-FY | Human Anti-CD52 Recombinant Antibody (HPAB-0387-FY) | WB | Humanized IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-021 | Rat Anti-CD52 Recombinant Antibody (clone CAMPATH-1G); scFv Fragment | WB, IHC, IF, FuncS | Rat scFv |
HPAB-0748-FY-F(E) | Mouse Anti-CD52 Recombinant Antibody (clone HI52); scFv Fragment | Inhib | Mouse scFv |
HPAB-0107-WJ-S(P) | Human Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0107-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-0387-FY-S(P) | Human Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0387-FY-S(P)) | WB | Human scFv |
HPAB-1836-FY-F(E) | Human Anti-CD52 Recombinant Antibody (clone 5E3); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-311LC | Humanized Anti-Human CD52 Recombinant Antibody | ELISA | Humanized antibody |
TAB-315LC | Anti-Human CD52 Recombinant Antibody (ANT1034) | ELISA, FC, FuncS | Humanized antibody |
TAB-311LC-S(P) | Humanized Anti-Human CD52 Recombinant Antibody scFv Fragment | ELISA | Humanized antibody |
TAB-311LC-F(E) | Humanized Anti-Human CD52 Recombinant Antibody Fab Fragment | ELISA | Humanized antibody |
TAB-315LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (ANT1034) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-312LC | Anti-Human CD52 Recombinant Antibody (CF1D12) | FuncS | |
TAB-313LC | Mouse Anti-CD52 Recombinant Antibody (TAB-313LC) | ELISA, FC | Mouse IgG |
TAB-312LC-S(P) | Anti-Human CD52 Recombinant Antibody scFv Fragment (CF1D12) | ELISA | |
TAB-312LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (CF1D12) | ELISA | |
TAB-313LC-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (TAB-313LC-F(E)) | FC, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-314LC | Human Anti-CD52 Recombinant Antibody (TAB-314LC) | FC, ELISA | Chimeric (mouse/human) IgG1 |
TAB-314LC-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (TAB-314LC-S(P)) | FC, ELISA | Mouse scFv |
TAB-314LC-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (TAB-314LC-F(E)) | FC, ELISA | Chimeric (mouse/human) Fab |
TAB-469CQ | Anti-Canine CD52 Recombinant Antibody (Tamtuvetmab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-038LC | Recombinant Anti-Human CD52 Antibody (Fab glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0568 | Hi-Affi™ Rabbit Anti-CD52 Recombinant Antibody (clone DS568AB) | WB, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-469CQ | Afuco™ Anti-CD52 ADCC Recombinant Antibody (Tamtuvetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0107-WJ-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0107-WJ-F(E)) | ELISA, FC | Humanized Fab |
HPAB-0940WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0940WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0941WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0941WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0942WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0942WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0943WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0943WJ-F(E)) | ELISA, FC | Mouse Fab |
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