Anti-Human CD52 Recombinant Antibody (ANT1034) (CAT#: TAB-315LC)

This product is a recombinant monoclonal antibody against CD52. This study demonstrates that it binds strongly to CD52-expressing cells and is more effective in directing antibody-dependent and complement-dependent cellular cytotoxicity. It is a humanized antibody with potential use in the treatment studies of chronic lymphocytic leukemia and autoimmune diseases.


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  • Size:
  • Conjugation:
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  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
FuncS

Figure 1 Kaplan-Meier survival curves for the in vivo assessment of ANT1034 and alemtuzumab.

Figure 1 Kaplan-Meier survival curves for the in vivo assessment of ANT1034 and alemtuzumab.

Antibodies were assessed in the Raji human Burkitt lymphoma SCID mouse model. Antibodies were administered on alternate days for seven doses starting 3 days post-injection of tumour cells. Efficacy was determined by comparing the median times to endpoint (either death, or euthanasia for advanced tumour progression).

Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.

FuncS

Figure 2 CD4+ Episcreen™ T cell proliferation responses to ANT1034, alemtuzumab and chimeric 2E8.

Figure 2 CD4+ Episcreen™ T cell proliferation responses to ANT1034, alemtuzumab and chimeric 2E8.

Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • ANT1034
  • Applications
  • ELISA, FC, FuncS
  • Related Disease
  • Chronic lymphocytic leukaemia, Autoimmune disease

Applications

  • Application Notes
  • This antibody has been tested for use in Function Assay. Please see the Published Data for further information.

Target

  • Alternative Names
  • CDW52; CD52

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone ANT1034"

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Recombinant Antibody

Chimeric Antibody

Fab Glycosylation

CAT Product Name Application Type
Gly-038LC Recombinant Anti-Human CD52 Antibody (Fab glycosylation) ELISA Human antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0568 Hi-Affi™ Rabbit Anti-CD52 Recombinant Antibody (clone DS568AB) WB, IP Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-469CQ Afuco™ Anti-CD52 ADCC Recombinant Antibody (Tamtuvetmab), ADCC Enhanced ELISA, IHC, FC, IP, IF, FuncS ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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