This product is a recombinant monoclonal antibody against CD52. This study demonstrates that it binds strongly to CD52-expressing cells and is more effective in directing antibody-dependent and complement-dependent cellular cytotoxicity. It is a humanized antibody with potential use in the treatment studies of chronic lymphocytic leukemia and autoimmune diseases.
Figure 1 Kaplan-Meier survival curves for the in vivo assessment of ANT1034 and alemtuzumab.
Antibodies were assessed in the Raji human Burkitt lymphoma SCID mouse model. Antibodies were administered on alternate days for seven doses starting 3 days post-injection of tumour cells. Efficacy was determined by comparing the median times to endpoint (either death, or euthanasia for advanced tumour progression).
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
Figure 2 CD4+ Episcreen™ T cell proliferation responses to ANT1034, alemtuzumab and chimeric 2E8.
Holgate, R. G., Weldon, R., Jones, T. D., & Baker, M. P. (2015). Characterisation of a novel anti-CD52 antibody with improved efficacy and reduced immunogenicity. PLoS One, 10(9), e0138123.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1223z | Mouse Anti-CD52 Recombinant Antibody (clone 20C9) | WB, ELISA, FC, IHC, FuncS | Mouse IgG1, κ |
PABC-021 | Rat Anti-CD52 Recombinant Antibody (clone CAMPATH-1G) | WB, IHC, IF, FuncS | Rat IgG2b |
MOB-0508CT | Mouse Anti-CD52 Recombinant Antibody (clone IJ297) | FC, IHC-P | Mouse IgG2b |
HPAB-0748-FY | Mouse Anti-CD52 Recombinant Antibody (clone HI52) | Inhib | Mouse IgG |
HPAB-0107-WJ | Human Anti-CD52 Recombinant Antibody (HPAB-0107-WJ) | ELISA, FC, CDC, FuncS | Humanized IgG1, κ |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBC-021 | Rat Anti-CD52 Recombinant Antibody (clone CAMPATH-1G); scFv Fragment | WB, IHC, IF, FuncS | Rat scFv |
FAMAB-0045-YC-S(P) | Rat Anti-CD52 Recombinant Antibody (clone YTH 34.5HL); scFv Fragment | ELISA | Rat scFv |
HPAB-0748-FY-F(E) | Mouse Anti-CD52 Recombinant Antibody (clone HI52); scFv Fragment | Inhib | Mouse scFv |
HPAB-0107-WJ-S(P) | Human Anti-CD52 Recombinant Antibody; scFv Fragment (HPAB-0107-WJ-S(P)) | ELISA, FC | Human scFv |
HPAB-1836-FY-F(E) | Human Anti-CD52 Recombinant Antibody (clone 5E3); scFv Fragment | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-311LC | Humanized Anti-Human CD52 Recombinant Antibody | ELISA | Humanized antibody |
TAB-311LC-S(P) | Humanized Anti-Human CD52 Recombinant Antibody scFv Fragment | ELISA | Humanized antibody |
TAB-315LC-S(P) | Anti-Human CD52 Recombinant Antibody scFv Fragment (ANT1034) | FC, ELISA | Humanized antibody |
TAB-311LC-F(E) | Humanized Anti-Human CD52 Recombinant Antibody Fab Fragment | ELISA | Humanized antibody |
TAB-315LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (ANT1034) | FC, ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-312LC | Anti-Human CD52 Recombinant Antibody (CF1D12) | FuncS | |
TAB-312LC-S(P) | Anti-Human CD52 Recombinant Antibody scFv Fragment (CF1D12) | ELISA | |
TAB-313LC-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (TAB-313LC-S(P)) | FC, ELISA | Mouse scFv |
TAB-312LC-F(E) | Anti-Human CD52 Recombinant Antibody Fab Fragment (CF1D12) | ELISA | |
TAB-313LC-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (TAB-313LC-F(E)) | FC, ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-314LC | Human Anti-CD52 Recombinant Antibody (TAB-314LC) | FC, ELISA | Chimeric (mouse/human) IgG1 |
TAB-314LC-S(P) | Mouse Anti-CD52 Recombinant Antibody; scFv Fragment (TAB-314LC-S(P)) | FC, ELISA | Mouse scFv |
TAB-314LC-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (TAB-314LC-F(E)) | FC, ELISA | Chimeric (mouse/human) Fab |
TAB-469CQ | Anti-Canine CD52 Recombinant Antibody (Tamtuvetmab) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-038LC | Recombinant Anti-Human CD52 Antibody (Fab glycosylation) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0568 | Hi-Affi™ Rabbit Anti-CD52 Recombinant Antibody (clone DS568AB) | WB, IP | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-469CQ | Afuco™ Anti-CD52 ADCC Recombinant Antibody (Tamtuvetmab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0398-YJ-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0398-YJ-F(E)) | ELISA, Inhib, Immunocontraception | Human Fab |
HPAB-0387-FY-F(E) | Human Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0387-FY-F(E)) | WB | Humanized Fab |
HPAB-0940WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0940WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0941WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0941WJ-F(E)) | ELISA, FC | Mouse Fab |
HPAB-0942WJ-F(E) | Mouse Anti-CD52 Recombinant Antibody; Fab Fragment (HPAB-0942WJ-F(E)) | ELISA, FC | Mouse Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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