Anti-CD56 (huN901)-SPP-DM1 ADC (IMGN901/Lorvotuzumab mertansine) (CAT#: ADC-L017)

This ADC product is composed of an anti-CD56 antibody (clone huN901) conjuagated via a SPP linker to DM1 (huN901-SPP-DM1). It has demonstrated a response in MM treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Antibody Overview
  • Humanized IgG1k antibody J2898A (Anti-CD56)
  • Clone
  • huN901
  • Antibody Conjugation
  • Humanized
  • Linker
  • SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Linker Class/Description
  • Class: Chemically cleavable linker-Disulfide linker
    Description: Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
  • Drug
  • DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
  • Drug Class/Description
  • Class: Maytansinoid
    Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
    macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells.

Target

  • Introduction
  • This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CD56; NCAM; MSK39

Downloads

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Recombinant Antibody

Humanized Antibody

CAT Product Name Application Type
TAB-188 Humanized Anti-NCAM1 Recombinant Antibody (clone Lorvotuzumab) ELISA, FC, IP, FuncS, IF, Neut, ICC Humanized (from mouse) IgG1, κ

Immunotoxin

CAT Product Name Application Type
AGTO-L037R anti-NCAM1 immunotoxin N901 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L037P anti-NCAM1 immunotoxin N901 (IgG)-PAP Cytotoxicity assay, Functional assay

Blocking Antibody

CAT Product Name Application Type
NEUT-1761CQ Recombinant Mouse Anti-NCAM1 Antibody (MEM188) FC, IHC-Fr, ICC, Separation, BL IgG2a, κ

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-4549 Hi-Affi™ Recombinant Rabbit Anti-NCAM1 Monoclonal Antibody (TH59DS) WB, IF, ICC, FC IgG

Neuroscience Antibody

CAT Product Name Application Type
NS-054CN Mouse Anti-NCAM1 Recombinant Antibody (clone 5A2) ELISA, WB, IP, FC, FuncS Mouse IgG1

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-188 Afuco™ Anti-NCAM1 ADCC Recombinant Antibody (Lorvotuzumab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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