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Anti-CD66e-Mc-SN-38 ADC (IMMU-130/-SN-38) (CAT#: ADC-L020)

This ADC product is composed of an anti-CD66e antibody conjuagated to SN-38 (SN-38). It has demonstrated a response in CRC treatment by a MOA (Mechanism of Action) of Inhibit TopoisomeraseⅠand cause DNA damage.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Figure 1 IF staining of human cell line HaCaT
Figure 1 IF staining of human cell line HaCaT
(Immunofluorescent staining of human cell line HaCaT shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19758/1660_G5_2_selected.jpg
Figure 2 IHC staining of human duodenum
Figure 2 IHC staining of human duodenum
(Immunohistochemical staining of human duodenum shows strong cytoplasmic positivity in a subset of leukocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/11041/ihc_selected.jpg
Normal Tissue
Figure 3 Colon
Figure 3 Colon
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Gradient
Gradient: Ascending
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_7_3.jpg
Figure 4 Rectum
Figure 4 Rectum
(Endocrine cells
Staining: High
Intensity: Strong
Enterocytes
Staining: High
Intensity: Strong
Quantity:>75%
Enterocytes - Microvilli
Staining: High
Intensity: Strong
Goblet cells
Staining: High
Intensity: Strong
Quantity:>75%
Mucosal lymphoid cells
Staining: Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/21/19_A_6_3.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (OE19)
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5
Figure 5 RNA cell line category: Cell line enriched (OE19)
Figure 5 RNA cell line category: Cell line enriched (OE19)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105388-CEACAM5

Specifications

  • Antibody Overview
  • Humanized IgG1k antibody (Anti-CEA)
  • Antibody Conjugation
  • Humanized
  • Linker
  • mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linkers
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
  • Drug
  • SN-38 (7-ethyl-10-hydroxycamptothecin)
  • Drug Class/Description
  • Class: SN-38
    Description: SN38 (7-ethyl-10-hydroxy camptothecin) is an active metabolite of the cancer prodrug, irinotecan, with the ability of inhibiting Topoisomerase I, which is belong to the camptothecin family. SN-38 is formed via hydrolysis of irinotecan by carboxylesterases and metabolized via glucuronidation by UGT1A1

Target

  • Introduction
  • This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants.
  • Alternative Names
  • CEA; CD66e

Downloads

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Single-domain Antibody

CAT Product Name Application Type
NABL-080 Recombinant Anti-human CEACAM5 VHH Single Domain Antibody WB, ELISA, IHC, FC, FuncS Llama VHH
HPAB-0204-FY Recombinant llama Anti-CEACAM5 Antibody (11C12) ADCC, ELISA llama VHH
HPAB-0205-FY Recombinant llama Anti-CEACAM5 Antibody (15E7) ADCC, E llama VHH
HPAB-0206-FY Recombinant llama Anti-CEACAM5 Antibody (2C2) ADCC, E llama VHH
HPAB-1024WJ Recombinant Camelid Anti-CEACAM5 Single Domain Antibody SPR, Inhib Camelid VHH

Mouse Antibody

CAT Product Name Application Type
TAB-703 Anti-Human CEACAM5 Recombinant Antibody (Altumomab) IF, IP, Neut, FuncS, ELISA, FC, IHC IgG1
TAB-418LC-S(P) Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 9) FC, WB
TAB-419LC-S(P) Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 12) FC, WB
TAB-420LC-S(P) Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 13) FC, WB
TAB-421LC-S(P) Anti-Human CEACAM5 Recombinant Antibody scFv Fragment (COL-Human 15) FC, WB

Immunotoxin

CAT Product Name Application Type
AGTO-L003E anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L003R anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L004E anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L004R anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA Cytotoxicity assay, Functional assay

Chimeric Antibody

CAT Product Name Application Type
TAB-409LC-S(P) Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-409LC-S(P)) SPR, ELISA, FC Humanized scFv
TAB-412LC-S(P) Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-412LC-S(P)) FC, ELISA Human scFv
TAB-413LC-S(P) Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-413LC-S(P)) FC, ELISA Human scFv
TAB-409LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-409LC-F(E)) SPR, ELISA, FC Humanized Fab
TAB-412LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-412LC-F(E)) FC, ELISA Chimeric (Mouse/Human) Fab

Human Antibody

CAT Product Name Application Type
TAB-411LC-S(P) Human Anti-Human CEACAM5 Recombinant Antibody scFv Fragment ELISA Human antibody
TAB-411LC-F(E) Human Anti-Human CEACAM5 Recombinant Antibody Fab Fragment ELISA Human antibody

Humanized Antibody

CAT Product Name Application Type
TAB-414LC-S(P) Human Anti-CEACAM5 Recombinant Antibody; scFv Fragment (TAB-414LC-S(P)) FC, ELISA Human scFv
TAB-414LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-414LC-F(E)) FC, ELISA Humanized Fab
TAB-415LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-415LC-F(E)) FC, ELISA Humanized Fab
TAB-416LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-416LC-F(E)) FC, ELISA Humanized Fab
TAB-417LC-F(E) Human Anti-CEACAM5 Recombinant Antibody; Fab Fragment (TAB-417LC-F(E)) IF, ELISA Humanized Fab

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0118MZ Chicken Anti-CEACAM5 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0649 Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) IHC Rabbit IgG

Recombinant Antibody

CAT Product Name Application Type
HPAB-0155-FY Mouse Anti-CEACAM5 Recombinant Antibody (HPAB-0155-FY) Activ, FuncS Humanized IgG1, κ
MRO-0231-CN Rabbit Anti-CEACAM5 Recombinant Antibody (clone JM93-28) WB, IF, IHC Rabbit IgG
MRO-1770-CN Rabbit Anti-CEACAM5 Polyclonal Antibody (MRO-1770-CN) WB, IF, IHC, FC Rabbit IgG
FAMAB-1027CQ Human Anti-CEACAM5 Recombinant Antibody (clone EB-022) ELISA Human IgG1
FAMAB-1028CQ Human Anti-CEACAM5 Recombinant Antibody (clone EB-011) ELISA Human IgG1

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0155-FY-S(P) Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-0155-FY-S(P)) Activ Humanized scFv
HPAB-0243-FY-S(P) Mouse Anti-CEACAM5 Recombinant Antibody (clone M5A); scFv Fragment ELISA Mouse scFv
HPAB-0348-YJ-S(P) Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); scFv Fragment ELISA, IHC Mouse scFv
HPAB-1094WJ-S(P) Mouse Anti-CEACAM5 Recombinant Antibody; scFv Fragment (HPAB-1094WJ-S(P)) ELISA, FC Mouse scFv
HPAB-2106-FY-S(P) Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); scFv Fragment ELISA, FC, Inhib Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0155-FY-F(E) Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-0155-FY-F(E)) Activ Humanized Fab
HPAB-0243-FY-F(E) Human Anti-CEACAM5 Recombinant Antibody (clone M5A); Fab Fragment ELISA Chimeric (mouse/human) Fab
HPAB-0348-YJ-F(E) Mouse Anti-CEACAM5 Recombinant Antibody (clone 10E1); Fab Fragment ELISA, IHC Mouse Fab
HPAB-1094WJ-F(E) Mouse Anti-CEACAM5 Recombinant Antibody; Fab Fragment (HPAB-1094WJ-F(E)) ELISA, FC Mouse Fab
HPAB-2106-FY-F(E) Human Anti-CEACAM5 Recombinant Antibody (clone CEA6); Fab Fragment ELISA, FC, Inhib Human Fab, κ

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-703 Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody (Altumomab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

MHC Tetramer for Cancer

CAT Product Name Application Type
MHC-YF353 A*02:01/Human Carcinoembryonic antigen (CEA)-derived peptide CAP1-6D (YLSGADLNL) MHC Pentamer FCM
MHC-YF354 A*02:01/Human Carcinogenic Embryonic Antigen (CEA) (GVLVGVALI) MHC Pentamer FCM
MHC-YF355 A*24:02/Human Carcinogenic Embryonic Antigen (CEA) (TYACFVSNL) MHC Pentamer FCM
MHC-YF360 A*02:01/Human CEA (YLWWVNNQSL) MHC Pentamer FCM
MHC-YF361 B*07:02/Human CEACAM (LPVSPRLQL) MHC Pentamer FCM

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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