Products

Anti-CD7 Immunocytokine, scFv (scFv3A1F)-sFasL (ACFP-SH121)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD7 scFv to sFasL. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD7 as well as the biological activity of sFasL. The soluble protein was inactive and required binding to tumor cells expressing CD7 to induce a tumoricidal activity for the treatment of T-cell leukemia. The immunocytokine was applied to eliminate pathogenic synovial fluid Th1 and Treg cells from rheumatoid arthritis and juvenile idiopathic arthritis, thus expanding a possible therapeutic application to chronic inflammatory diseases. This immunocytokine was designed for treating chronic inflammatory diseases.      

Specifications
Target
CD7
Molecule Class
scFv-sFasL
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
scFv3A1F
Related Disease
Chronic inflammatory diseases
Cytokines 1
sFasL
Cytokines 1 Description
Fas ligand (FasL or CD95L) is a type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD7; CD7 molecule; GP40; TP41; Tp40; LEU-9; T-cell antigen CD7; p41 protein
Entrez Gene ID
924
UniProt ID
P09564

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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