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Anti-CD72 immunotoxin J3-109 (IgG)-PAP (AGTO-G083P)

This immunotoxin was achieved by conjugating/fusing the Anti-CD72 monoclonal antibody to Pokeweed antiviral protein. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and the toxin enters cells by receptor-mediated endocytosis. Then PAP is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes. It was designed for treatment of acute lymphoblastic leukemias (ALL).      

Specifications
Host
Mouse
Species Reactivity
Human
Clone
J3-109
Molecule Class
IgG-PAP
Toxin Description
Pokeweed antiviral protein (PAP) is a type I ribosome inactivating protein isolated from the pokeweed plant, Phytolacca americana. The toxin is introduced into the cytoplasm where it eventually causes cell death by inactivating ribosomes.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Acute lymphoblastic leukemias (ALL)
Target
Alternative Names
CD72; CD72 molecule; LYB2; CD72b; B-cell differentiation antigen CD72; lyb-2; CD72 antigen; Pokeweed Antiviral Protein
Entrez Gene ID
971
UniProt ID
P21854

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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