Products

Anti-CD8 Immunocytokine, TNF-IgG (OKT8) (ACFP-SH120)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CD8 IgG to TNF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the CD8 as well as the biological activity of TNF. TNF-FuP significantly accumulated in the tumor, which led to retardation of tumor growth. The fusion protein stimulated cytokine production and cytotoxic activity of monocytes and, to a low degree, of T cells. The therapeutic effect was improved by intratumoral application. Importantly, the efficacy of TNF-FuP depended on the induction of an immune response in vivo. This immunocytokine was designed for treating tumor.      

Specifications
Target
CD8
Molecule Class
TNF-IgG2a
Species Reactivity
Human
Host
Mouse
Expression Host
CHO
Clone
OKT8
Related Disease
Tumor
Cytokines 1
TNF
Cytokines 1 Description
Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. The primary role of TNF is in the regulation of immune cells. TNF, being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease, cancer, major depression, Psoriasis and inflammatory bowel disease (IBD). While still controversial, studies of depression and IBD are currently being linked to TNF levels. Recombinant TNF is used as an immunostimulant under the INN tasonermin. TNF can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CD8A; CD8a molecule; CD8; MAL; p32; Leu2; T-cell surface glycoprotein CD8 alpha chain; T8 T-cell antigen
Entrez Gene ID
925
UniProt ID
P01732

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved