anti-CD80 immunotoxin 6G7 (IgG)-Bouganin (CAT#: AGTO-L001O)
This immunotoxin was achieved by conjugating/fusing the anti-CD80 monoclonal antibody to Bouganin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD80-expressing cells. Once bind, the toxin enters cells by receptor-mediated endocytosis and enzymatically damages ribosomes, ultimately leading to cell death. It was designed for treatment of Hodgkin's disease or other CD80-expressing tumours.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Bone marrow
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
(Hematopoietic cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56116_B_6_4.jpg
Figure 2 Lymph node
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
(Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25368/56076_A_9_8.jpg
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
Figure 3 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000121594-CD80
Specifications
- Host Species
- Mouse
- Species Reactivity
- Human
- Clone
- 6G7
- Molecule Class
- L kappa; IgG1-Bouganin
- Toxin Description
- Bouganin is a type-I ribosome inactivating protein (RIP) that was recently purified from leaves of Bougainvillea spectabilis Willd. Like all type-I RIPs, bouganin is a RNA glycosidase with deadenylating activity. Bouganin was characterized as a single-chain protein with a molecular mass of 26 200 Da and its mature protein consists of 250 amino acids. Furthermore, it was found that bouganin is probably the least toxic RIP known based on protein inhibiting studies in cell lines. It was observed that the bouganin concentrations inhibiting protein synthesis of human cell lines were much higher than the concentrations required to inhibit protein synthesis in a rabbit reticulocyte lysate assay, a characteristic common to all type-I RIPs.
- Applications
- This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
- Related Disease
- Hodgkin's lymphoma
Target
- Alternative Names
- CD80; CD80 molecule; B7; BB1; B7-1; B7.1; LAB7; CD28LG; CD28LG1; T-lymphocyte activation antigen CD80; activation B7-1 antigen; costimulatory factor CD80; CTLA-4 counter-receptor B7.1; B-lymphocyte activation antigen B7; costimulatory molecule variant IgV-CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); Hodgkin's lymphoma; lymphoma; Bouganin
- Gene ID
- 941
- UniProt ID
- P01589
Related Resources
Rheumatoid Arthritis
Systemic Lupus Erythematosus
Allograft Rejection
Autoimmune Thyroid Disease
Graft-versus-Host Disease
Maturity Onset Diabetes of the Young
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 6G7"
See other products for "CD80"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-215 | Anti-Human CD80 Recombinant Antibody (Galiximab) | WB, ELISA, FC, IP, FuncS, IF, Neut | IgG1 - lambda |
Immunotoxin
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-L001G | anti-CD80 immunotoxin 6G7 (IgG)-Gel | Cytotoxicity assay, Functional assay | |
| AGTO-L001S | anti-CD80 immunotoxin 6G7 (IgG)-Sap | Cytotoxicity assay, Functional assay |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-347LC | Mouse Anti-CD80 Recombinant Antibody (TAB-347LC) | FC | Mouse IgG |
| TAB-347LC-S(P) | Mouse Anti-CD80 Recombinant Antibody; scFv Fragment (TAB-347LC-S(P)) | FC | Mouse scFv |
| TAB-347LC-F(E) | Mouse Anti-CD80 Recombinant Antibody; Fab Fragment (TAB-347LC-F(E)) | FC | Mouse Fab |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-159LC | Recombinant Anti-Human CD80 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
Low- or Non-fucosylated Oligosaccharide
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-159LC-1 | Recombinant Anti-Human CD80 Antibody (Fc glycosylation/Non fucosylated) | ELISA | Chimeric antibody (primate/human) |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0490CT | Recombinant Mouse anti-Human CD80 Monoclonal antibody (NFN-344) | FC | |
| MRO-0318-CN | Rabbit Anti-CD80 Recombinant Antibody (clone JF100-4) | WB, IHC | Rabbit IgG |
| MRO-0319-CN | Mouse Anti-CD80 Recombinant Antibody (clone 8-E5) | WB, IF, IHC, FC | Mouse IgG2b |
| FN-040CQ | Mouse Anti-CD80 Recombinant Antibody (clone BB1) | FC, ELISA, WB, Block | Mouse IgM, κ |
| FN-057CQ | Mouse Anti-CD80 Recombinant Antibody (clone P1.H1.A1.A1) | FC, ELISA, FuncS | Mouse IgG1 |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0066MZ | Chicken Anti-BB1 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-409CQ | Mouse Anti-CD80 Recombinant Antibody (clone CBL764) | FC, IHC, CyTOF®, ELISA, Neut | Mouse IgG1 |
| NEUT-410CQ | Mouse Anti-CD80 Recombinant Antibody (clone 6N36) | FC, IHC, Neut, WB | Mouse IgG1 |
| NEUT-411CQ | Mouse Anti-CD80 Recombinant Antibody (clone AS29) | IP, Neut | Mouse IgG1 |
| NEUT-412CQ | Mouse Anti-CD80 Recombinant Antibody (VMC172) | Neut, FC | Mouse IgG1 |
| NEUT-415CQ | Hamster Anti-Cd80 Recombinant Antibody (clone 16-10A1) | FC, FuncS, Neut, IHC, IHC-Fr | Hamster IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-413CQ | Rat Anti-Cd80 Recombinant Antibody (clone 1G10) | IP, Block | Rat IgG2a, κ |
| NEUT-414CQ | Hamster Anti-Cd80 Recombinant Antibody (clone MAB0826) | Block, FC, IHC-Fr | Hamster IgG |
| NEUT-416CQ | Mouse Anti-Cd80 Recombinant Antibody (clone 3H5) | Block, FC | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0583 | Hi-Affi™ Rabbit Anti-CD80 Recombinant Antibody (clone DS583AB) | WB, IHC | Rabbit IgG |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-215 | Afuco™ Anti-CD80 ADCC Recombinant Antibody (Galiximab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF | ADCC enhanced antibody |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0063-YJ-S(P) | Human Anti-CD80 Recombinant Antibody (clone hu1F1); scFv Fragment | ELISA, FuncS | Humanized scFv |
| HPAB-0708-FY-F(E) | Mouse Anti-CD80 Recombinant Antibody (clone AB007); scFv Fragment | ELISA | Mouse scFv |
| HPAB-1587WJ-S(P) | Mouse Anti-CD80 Recombinant Antibody; scFv Fragment (clone 1F1) | ELISA, WB | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0063-YJ-F(E) | Human Anti-CD80 Recombinant Antibody (clone hu1F1); Fab Fragment | ELISA, FuncS | Humanized Fab |
| HPAB-0708-FY-S(P) | Mouse Anti-CD80 Recombinant Antibody (clone AB007); Fab Fragment | ELISA | Mouse Fab |
| HPAB-1587WJ-F(E) | Mouse Anti-CD80 Recombinant Antibody; Fab Fragment (clone 1F1) | ELISA, WB | Mouse Fab |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for AGTO-L001O. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.