Products

anti-CD86 immunotoxin 1G10 (IgG)-Sap (AGTO-L002S)

This immunotoxin was achieved by conjugating/fusing the anti-CD86 monoclonal antibody to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to CD86-expressing cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of Hodgkin's disease or other CD86-expressing tumours.      

Specifications
Host
Rat
Species Reactivity
Mouse
Clone
1G10
Molecule Class
L kappa; IgG2a-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
Hodgkin's lymphoma
Target
Alternative Names
CD86; CD86 molecule; B70; B7-2; B7.2; LAB72; CD28LG2; T-lymphocyte activation antigen CD86
Entrez Gene ID
942
UniProt ID
A5D8T4

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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