This product is a recombinant mouse antibody that recognizes CDCP1. The antibody is internalized after binding and can kill PC-3 cells during in vitro transplantation and invasion in vitro. antibody treatment at 0.8 μM resulted in a 78% inhibition of PC-3 cell migration compared to the PBS/complete medium control.
Figure 1 FACS profile of chimeric 25Al 1 IgG on PC-3, DuI 45 cell lines.
LN met is lymph node metastasis. GFI is the geometric mean of fluorescence intensity.
Figure 2 IHC staining of 25Al 1 on 1 : PC-3 cells, secondary alone (negative control), 2: PC-3 cells (positive control), 3: Patient 2, benign glands, 4: Patient 2, malignant glands, 5: Patient 5, benign glands, 6: Patient 5, malignant glands.
Figure 3 Summary of cell migration and invasion assays. PC-3 cells were treated with titrations of ch25Al 1 or CUBl, or 2.5 μM of PP2 and tested in Boyden chambers for inhibition of cell migration and invasion.
Figure 4 shows the internalization assay using anti-CDCPl antibodies with appropriate saporin secondary conjugates, or with ch25Al 1-Sap direct conjugate.
Figure 5 Effect of ch25Al 1 -saporin direct conjugate on PC-3 tumor growth.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-149CL | Human Anti-CDCP1 Recombinant Antibody (TAB-149CL) | FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-403LC | Anti-Human CDCP1 Recombinant Antibody (25A11) | FC, FuncS, IHC | |
TAB-403LC-S(P) | Anti-Human CDCP1 Recombinant Antibody scFv Fragment (25A11) | FC, IHC, ELISA | |
TAB-403LC-F(E) | Anti-Human CDCP1 Recombinant Antibody Fab Fragment (25A11) | FC, IHC, ELISA |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-404LC-S(P) | Anti-Human CDCP1 Recombinant Antibody scFv Fragment (ch25A11) | FC, IHC, ELISA | Chimeric antibody (mouse/human) |
TAB-404LC-F(E) | Anti-Human CDCP1 Recombinant Antibody Fab Fragment (ch25A11) | FC, IHC, ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-4074 | Hi-Affi™ Rabbit Anti-CDCP1 Recombinant Antibody (clone SI141DS) | ELISA | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1060-FY-S(P) | Human Anti-CDCP1 Recombinant Antibody (clone 65E8); Fab Fragment | ELISA, FC | Human Fab |
HPAB-1063WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1063WJ-F(E)) | ELISA | Mouse Fab |
HPAB-1064WJ-F(E) | Human Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1064WJ-F(E)) | ELISA | Humanized Fab |
HPAB-1070WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1070WJ-F(E)) | ELISA | Mouse Fab |
HPAB-1071WJ-F(E) | Mouse Anti-CDCP1 Recombinant Antibody; Fab Fragment (HPAB-1071WJ-F(E)) | ELISA | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1063WJ | Mouse Anti-CDCP1 Recombinant Antibody (HPAB-1063WJ) | ELISA | Mouse IgG |
HPAB-1064WJ | Human Anti-CDCP1 Recombinant Antibody (HPAB-1064WJ) | ELISA | Humanized IgG |
HPAB-1070WJ | Mouse Anti-CDCP1 Recombinant Antibody (HPAB-1070WJ) | ELISA | Mouse IgG |
HPAB-1071WJ | Mouse Anti-CDCP1 Recombinant Antibody (HPAB-1071WJ) | ELISA | Mouse IgG |
HPAB-1072WJ | Mouse Anti-CDCP1 Recombinant Antibody (HPAB-1072WJ) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1063WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1063WJ-S(P)) | ELISA | Mouse scFv |
HPAB-1064WJ-S(P) | Human Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1064WJ-S(P)) | ELISA | Humanized scFv |
HPAB-1070WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1070WJ-S(P)) | ELISA | Mouse scFv |
HPAB-1071WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1071WJ-S(P)) | ELISA | Mouse scFv |
HPAB-1072WJ-S(P) | Mouse Anti-CDCP1 Recombinant Antibody; scFv Fragment (HPAB-1072WJ-S(P)) | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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