Anti-Human CDH1 Recombinant Antibody (hSC10.17) (CAT#: TAB-1411CL)
This is a humanized antibody anti-CD324 modulator. This antibody has an estimated KD of 3.8 nM. humanized CD324 modulator antibody kills CD324-expressing cells with an EC₅₀ of 4.4 pM.
Specific Inquiry
Figure 1 Humanized CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin and where the determined EC50 (e.g., half-maximal effective concentration) values are indicative of efficient cell killing.
FuncS
Figure 1 illustrating that CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin, and the EC50 (e.g., half-maximal effective concentration) was determined for selected modulators.
Cyt
Figure 2 is a graphical representation demonstrating that the disclosed CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to various patient-derived non-traditional xenograft cells expressing CD324 wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin.
Inhib
Figure 3 illustrates the ability of the disclosed modulators to inhibit CD324 homotypic binding.
FuncS
Figure 4 demonstrates that humanized CD324 modulators may effectively be used as targeting moieties to direct cytotoxic payloads to cells expressing CD324, wherein the decrease in normalized RLU value is indicative of cell killing through internalized toxin and where the determined EC50 (e.g., half-maximal effective concentration) values are indicative of efficient cell killing.
Specifications
- Host Species
- Human
- Type
- Humanized antibody
- Specificity
- Human
- Clone
- hSC10.17
- Applications
- Cyt, FuncS, Inhib
- Related Disease
- CD324 associated disorders (e.g., hyperproliferative disorders or neoplastic disorders)
Applications
- Application Notes
- This antibody has been reported for use in Cytotoxicity, Functional Assay, Inhibition.
Target
- Alternative Names
- CDH1; cadherin 1, type 1, E-cadherin (epithelial); UVO; CDHE; ECAD; LCAM; Arc-1; CD324; cadherin-1; CAM 120/80; E-Cadherin; uvomorulin; cell-CAM 120/80; epithelial cadherin; cadherin 1, E-cadherin (epithelial); calcium-dependent adhesion protein, epithelial;
- Gene ID
- 999
- UniProt ID
- P12830
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1472z | Mouse Anti-CDH1 Recombinant Antibody (clone 25C1) | WB, FC, ICC, IF, IHC | Mouse IgG1, κ |
| MRO-1830-CN | Rabbit Anti-CDH1 Polyclonal Antibody (MRO-1830-CN) | WB, IF, IHC, FC | Rabbit IgG |
| HPAB-0464-WJ | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6) | ELISA, FC | Mouse IgG |
| HPAB-0465-WJ | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15) | ELISA, FC | Mouse IgG |
| HPAB-0466-WJ | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17) | ELISA, FC | Mouse IgG |
Mouse Antibody
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1411CL-S(P) | Anti-Human CDH1 Recombinant Antibody scFv Fragment (hSC10.17) | ELISA | Humanized antibody |
| TAB-1411CL-F(E) | Anti-Human CDH1 Recombinant Antibody Fab Fragment (hSC10.17) | ELISA | Humanized antibody |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0111MZ | Chicken Anti-CDH1 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-440CQ | Rat Anti-CDH1 Recombinant Antibody (clone DECMA-1) | FC, FuncS, Neut, WB, IF, IP | Rat IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-441CQ | Rat Anti-Cdh1 Recombinant Antibody (clone ECCD-1) | IHC-Fr, Block, ICC, IF, WB | Rat IgG1 |
| NEUT-442CQ | Mouse Anti-CDH1 Recombinant Antibody (VMC173) | ELISA, FC, ICC, IF, IHC, IP, WB, IHC-P, IHC-Fr, Block | Mouse IgG1 |
| NEUT-443CQ | Mouse Anti-CDH1 Recombinant Antibody (VMC174) | ELISA, IP, WB, ICC, Block, FC, IHC-P | Mouse IgG2a |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0611 | Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone DS611AB) | ICC, IF, IHC-P, IHC-P, IP, WB | Rabbit IgG |
| MOR-4569 | Hi-Affi™ Rabbit Anti-CDH1 Recombinant Antibody (clone TH81DS) | WB, IF, ICC, FC | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0464-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0465-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0466-WJ-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); Fab Fragment | ELISA, FC | Mouse Fab |
| HPAB-0467-WJ-F(E) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); Fab Fragment | ELISA, FC | Humanized Fab |
| PABJ-0035-F(E) | Mouse Anti-CDH1 Recombinant Antibody (clone 66E8); Fab fragment | ELISA | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0464-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.6); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0465-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.15); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0466-WJ-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone SC10.17); scFv Fragment | ELISA, FC | Mouse scFv |
| HPAB-0467-WJ-S(P) | Human Anti-CDH1 Recombinant Antibody (clone hSC10.17); scFv Fragment | ELISA, FC | Humanized scFv |
| PABJ-0035-S(P) | Mouse Anti-CDH1 Recombinant Antibody (clone 66E8); scFv Fragment | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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