Anti-CEA Antibody-Cytokine Fusion Protein, p40-ScFv (T84.66)-p35 (CAT#: ACFP-SH169)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CEA ScFv to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the CEA as well as the biological activity of IL12. The aCEA-(hIL12) fusion protein induced the in vitro proliferation of PHA-PBMC and was able to induce LAK cells to inhibit the in vitro growth of TFK-1 cells (human bile duct carcinoma). This Immunocytokines was designed for treating human bile duct carcinoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Subcellular Location
Normal Tissue
RNA Expression

Specifications

  • Target
  • CEA
  • Molecule Class
  • p40-scFv-p35
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • T84.66
  • Related Disease
  • Human bile duct carcinoma
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100

Downloads

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See other products for "CEACAM5"

Immunotoxin

CAT Product Name Application Type
AGTO-L003E anti-CEACAM5 immunotoxin BDI-1 (IgG)-PE Cytotoxicity assay, Functional assay
AGTO-L003R anti-CEACAM5 immunotoxin BDI-1 (IgG)-RTA Cytotoxicity assay, Functional assay
AGTO-L004E anti-CEACAM5 immunotoxin BDI-1 (scFv)-PE Cytotoxicity assay, Functional assay
AGTO-L004R anti-CEACAM5 immunotoxin BDI-1 (scFv)-RTA Cytotoxicity assay, Functional assay

Humanized Antibody

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0118MZ Chicken Anti-CEACAM5 Polyclonal IgY WB Chicken antibody

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0649 Hi-Affi™ Rabbit Anti-CEACAM5 Recombinant Antibody (clone DS649AB) IHC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-703 Afuco™ Anti-CEACAM5 ADCC Recombinant Antibody (Altumomab), ADCC Enhanced IF, IP, Neut, FuncS, ELISA, FC ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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