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Anti-CEA Immunocytokine, p40-ScFv (T84.66)-p35 (ACFP-SH169)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-CEA ScFv to IL12. It was expressed in CHO and purified with affinity chromatography. The Immunocytokines retains the ability to bind the CEA as well as the biological activity of IL12. The aCEA-(hIL12) fusion protein induced the in vitro proliferation of PHA-PBMC and was able to induce LAK cells to inhibit the in vitro growth of TFK-1 cells (human bile duct carcinoma). This Immunocytokines was designed for treating human bile duct carcinoma.      

Specifications
Target
CEA
Molecule Class
p40-scFv-p35
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
T84.66
Related Disease
Human bile duct carcinoma
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100
Entrez Gene ID
1048
UniProt ID
A0A024R0K5

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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