Human Anti-CFD Recombinant Antibody (clone AFD) (CAT#: PABC-140)

Recombinant Human Antibody (AFD) is capable of binding to CFD, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-CFD mAb and CH1-3 region of human IgG and a light chain (LC) encoding VL from anti-CFD proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. AFD inhibits FD proteolytic function by interfering with macromolecular substrate access rather than by inhibiting FD catalysis, providing the molecular basis of AFD-mediated inhibition of a rate-limiting step in the alternative complement pathway.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
RNA Expression

Specifications

  • Host Species
  • Human
  • Type
  • Human IgG
  • Specificity
  • Human CFD
  • Species Reactivity
  • Human
  • Clone
  • AFD
  • Applications
  • Neut

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • CFD; complement factor D (adipsin); DF; ADN; PFD; ADIPSIN; complement factor D; properdin factor D; C3 convertase activator; complement factor D preproprotein; D component of complement (adipsin)

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone AFD"

See other products for "CFD"

Humanized Antibody

CAT Product Name Application Type
TAB-754 Anti-CFD Recombinant Antibody (Lampalizumab) ELISA, IP, FC, FuncS, Neut, IF Fab - G1 - kappa

Recombinant Antibody

Single-domain Antibody

CAT Product Name Application Type
PNBL-034 Recombinant Anti-CHRM2 VHH Single Domain Antibody (9-8) FACS Llama VHH

Rabbit Monoclonal Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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