This product is a recombinant mouse anti-Chikungunya virus monoclonal antibody. 3E4 specifically binds to E2 protein associated with Chikungunya virus and can be potentially used in the treatment and diagnosis of Chikungunya virus infection.
Figure 1 Sensitivity of E2 detection using anti-CHIK E2 MAbs.
Kinetic ranking assays on antibody-producing hybridoma supernatants. The curves show the monitored binding in resonance unit (RU) of 50 mM CHIK.sE2 protein on antibody-producing hybridoma supernatants 3C3, 3E4, 5A8, 6F2, 8A4, and 9B5 over time.
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein
Figure 2 Reactivity of anti-CHIK.E2 MAbs with endogenously synthesized E2 in infected cells.
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein
Figure 3 Reactivity of anti-CHIK.E2 MAbs with endogenously synthesized E2 in infected cells.
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein
Figure 4 Reactivity of anti-CHIK.E2 MAbs to reduced E2 proteins was determined by immunoblot analysis.
Membranes blotted with 100 ng of purified CHIK.sE2 protein (lane 1) or 105 FFU of sucrose-purified CHIK virus (lane 2) and were individually incubated with MAb 3C3, 3E4, or 8A4 as described in Materials and methods. Anti-CHIK HMAF was used as a positive control.
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein
Figure 5 Sensitivity of antigen-capture ELISA using anti-CHIK E2 MAbs.
Quantitative analysis was performed using MAb 8A4 as capture antibody and MAb 3E4 as detecting antibody and virus culture supernatants (A) and recombinant soluble CHIK.sE2 glycoprotein as viral antigen (B).
Production and characterization of mouse monoclonal antibodies reactive to Chikungunya envelope E2 glycoprotein
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
PABL-430 | Recombinant Human Anti-CHIKV E2 Antibody (CHK265) | IB, ELISA, BL | IgG |
PABL-431 | Recombinant Mouse Anti-CHIKV E2 Antibody (CHK9) | Neut, BL | IgG |
MOB-152CQ | Mouse Anti-CHIKV E2 Antibody (CHK265) | Neut, ELISA, IF, FC | Mouse IgG1, λ |
HPAB-S0184-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152) | Neut, FRNT, FuncS | Human IgG |
HPAB-S0185-YC | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152 N297Q) | Neut, FRNT, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBL-427 | Recombinant Human Anti-CHIKV E2 Antibody Fab Fragment (CHK265) | Neut | Fab |
PFBL-428 | Recombinant Mouse Anti-CHIKV E2 Antibody Fab Fragment (CHK9) | Neut, BL | Fab |
HPAB-S0184-YC-F(E) | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152); Fab Fragment | Neut, FRNT, FuncS | Human Fab |
HPAB-S0185-YC-F(E) | Human Anti-CHIKV E2 Recombinant Antibody (clone ch-CHK-152 N297Q); Fab Fragment | Neut, FRNT, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-427 | Recombinant Human Anti-CHIKV E2 Antibody scFv Fragment (CHK265) | Neut | scFv |
PSBL-428 | Recombinant Mouse Anti-CHIKV E2 Antibody scFv Fragment (CHK9) | Neut, BL | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1158LC | Anti-CHIKV E2 Recombinant Antibody (3C3) | ELISA, WB, IF, FC | Mouse Antibody |
MRO-1160LC | Anti-CHIKV E2 Recombinant Antibody (8A4) | ELISA, WB, IF, FC | Mouse Antibody |
MRO-1158LC-F(E) | Anti-CHIKV E2 Recombinant Antibody Fab Fragment (3C3) | ELISA, WB, IF | Mouse Antibody |
MRO-1159LC-F(E) | Anti-CHIKV E2 Recombinant Antibody Fab Fragment (3E4) | ELISA, WB, IF | Mouse Antibody |
MRO-1160LC-F(E) | Anti-CHIKV E2 Recombinant Antibody Fab Fragment (8A4) | ELISA, WB, IF | Mouse Antibody |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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