Mouse Anti-CII Recombinant Antibody (clone M2139) (CAT#: PABL-048)

Figure 1 ACC1-mediated arthritis in mice by passive transfer.

Four groups of B10.Q mice (6 mice in each group) were injected with PBS, ACC1, M2139, and a cocktail of M2139+ACC1, respectively. All mice received 25 μg LPS from E. coli intraperitoneally on day 5.

Ge, C., Tong, D., Liang, B., Lönnblom, E., Schneider, N., Hagert, C., ... & Fields, G. B. (2017). Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI insight, 2(13).

Figure 2 The cartilage binding of ACC1 to mouse cartilage was evaluated by immunohistochemical staining in vitro.

The knee joints and paws from adult mice were stained with H&E. Scale bar: 100 μm

Ge, C., Tong, D., Liang, B., Lönnblom, E., Schneider, N., Hagert, C., ... & Fields, G. B. (2017). Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage. JCI insight, 2(13).