Anti-Human CLDN4 Recombinant Antibody (Humanized KM3900) (CAT#: TAB-503LC)

Recombinant monoclonal antibody to CLDN4. Humanized KM3900 is a humanized antibody that can be potentially used in the treatment of pancreatic cancer .


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  • Published Data
  • Gene Expression
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FC

Figure 1 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/CHO) was measured by ABI 8200. The ordinate shows fluorescence intensity.

Figure 1 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/CHO) was measured by ABI 8200. The ordinate shows fluorescence intensity.

FC

Figure 2 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/C10C) was measured by FCM. The ordinate shows the number of cells, and the abscissa shows fluorescence intensity.

Figure 2 shows results in which the reactivity of an anti-CLDN4 monoclonal antibody KM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) and vector-introduced CHO cell (Vector/C10C) was measured by FCM. The ordinate shows the number of cells, and the abscissa shows fluorescence intensity.

WB

Figure 3 shows the reactivity of an anti-CLDN4 monoclonal antibody KM3900 by Western blotting.

Figure 3 shows the reactivity of an anti-CLDN4 monoclonal antibody KM3900 by Western blotting.

FC

Figure 4 shows results in which the reactivity of a negative control antibody mouse IgG2a and anti-CLDN4 monoclonal antibodies KM3900 and KM3907 for human cancer cell lines, MCF7 (breast cancer), HT-29 (colorectal cancer), SW480 (colorectal cancer), 22Rv1 (prostate cancer), DU 145 prostate cancer) and PC-3 (prostate cancer), was measured by FCM.

Figure 4 shows results in which the reactivity of a negative control antibody mouse IgG2a and anti-CLDN4 monoclonal antibodies KM3900 and KM3907 for human cancer cell lines, MCF7 (breast cancer), HT-29 (colorectal cancer), SW480 (colorectal cancer), 22Rv1 (prostate cancer), DU 145 prostate cancer) and PC-3 (prostate cancer), was measured by FCM.

Cyt

Figure 5 shows results in which the ADCC activity of an anti-CLDN4 human chimeric antibody cKM3900.

Figure 5 shows results in which the ADCC activity of an anti-CLDN4 human chimeric antibody cKM3900.

Cyt

Figure 6 shows results in which the CDC activity of an anti-CLDN4 human chimeric antibody cKM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) was measured. The ordinate shows CDC activity (%), and the abscissa shows the antibody concentration.

Figure 6 shows results in which the CDC activity of an anti-CLDN4 human chimeric antibody cKM3900 for CLDN4-myc/His gene-introduced CHO cell (CLDN4/CHO) was measured. The ordinate shows CDC activity (%), and the abscissa shows the antibody concentration.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Clone
  • Humanized KM3900
  • Applications
  • Cyt, FC, WB
  • Related Disease
  • Pancreatic cancer

Product Property

  • Preservative
  • Human
  • Storage
  • CLDN4 (claudin 4)

Applications

  • Application Notes
  • This antibody has been reported for use in Cytotoxicity, Flow Cytometry, Western Blot.

Target

  • Alternative Names
  • CLDN4; claudin 4; CPER; CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; claudin-4; CPE-receptor; Clostridium perfringens enterotoxin receptor 1; Williams-Beuren syndrome chromosomal region 8 protein

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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