Afuco™ Anti-Human CLU ADCC Recombinant Antibody (AB-16B5), ADCC Enhanced (CAT#: AFC-168CL)
Anti-CLU ADCC Enhanced Antibody (AB-16B5) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a humanized IgG2 antibody against an EMT-inducing form of secreted clusterin (sCLU). AB-16B5 very efficiently blocks EMT and pre-clinical data indicate that animals xenografted with various carcinoma cells show an increase of response to standard of care chemotherapy as well as a reduction of invasion.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/1919_G12_2_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/1919_G12_2_selected.jpg
Figure 2 IF staining of human cell line A549
(Immunofluorescent staining of human cell line A549 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/2064_D2_1_blue_red_green.jpg
(Immunofluorescent staining of human cell line A549 shows localization to cytosol.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/75983/2064_D2_1_blue_red_green.jpg
Figure 3 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_B_7_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_B_7_5.jpg
Figure 4 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_6_6.jpg
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_6_6.jpg
Figure 5 Epididymis
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_3_6.jpg
(Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/572/1519_A_3_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (HeLa, SK-BR-3, T-47d, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120885-CLU
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120885-CLU
Specifications
- Host Species
- Humanized
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Related Disease
- Cancer
Product Property
- Purity
- >90% assessed by SDS-PAGE
- Storage
- ≥1 year at -20°C. If the reconstituted antibody cannot be used within two weeks, it should be aliquoted into smaller vials and stored at -20°C
Target
- Alternative Names
- CLU; clusterin; CLI; AAG4; APOJ; CLU1; CLU2; KUB1; SGP2; APO-J; SGP-2; SP-40; TRPM2; TRPM-2; NA1/NA2; apolipoprotein J; ku70-binding protein 1; sulfated glycoprotein 2; aging-associated protein 4; complement lysis inhibitor; complement cytolysis inhibitor; complement-associated protein SP-40, 40; testosterone-repressed prostate message 2
- Gene ID
- 1191
- UniProt ID
- P10909
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "CLU"
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-690-VHH | Recombinant Anti-Human CLU VHH Single Domain Antibody | ICC, FC, WB, FUNC | Llama VHH |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-178CL | Human Anti-CLU Recombinant Antibody (TAB-178CL) | FuncS, Inhib | Human IgG2 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-533LC | Mouse Anti-CLU Recombinant Antibody (TAB-533LC) | WB | Mouse IgG |
| TAB-533LC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (TAB-533LC-S(P)) | WB | Mouse scFv |
| TAB-533LC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (TAB-533LC-F(E)) | WB | Mouse Fab |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0735 | Hi-Affi™ Rabbit Anti-CLU Recombinant Antibody (clone DS735AB) | IHC-P, WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC | Mouse Anti-CLU Recombinant Antibody (HPAB-0203-YC) | ELISA, FC, RIA | Mouse IgG |
| HPAB-0204-YC | Human Anti-CLU Recombinant Antibody (HPAB-0204-YC) | ELISA, FC, RIA | Humanized IgG |
| FAMAB-1093CQ | Mouse Anti-CLU Recombinant Antibody (clone SAIC-43B-8) | Immuno-MRM, WB, ELISA | Mouse IgG1 |
| MOB-298YJL | Rabbit Anti-CLU Recombinant Antibody (clone CBC281) | ELISA | Rabbit IgG |
| VS-0923-FY41 | Recombinant Mouse Anti-CLU Antibody (VS-0923-FY41) | ELISA, WB | Mouse IgG1 |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-S(P) | Mouse Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0203-YC-S(P)) | ELISA, FC, RIA | Mouse scFv |
| HPAB-0204-YC-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0204-YC-S(P)) | ELISA, FC, RIA | Humanized scFv |
| HPAB-0440LY-S(P) | Human Anti-CLU Recombinant Antibody; scFv Fragment (HPAB-0440LY-S(P)) | ELISA, RIA, FC | Humanized scfv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-YC-F(E) | Mouse Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0203-YC-F(E)) | ELISA, FC, RIA | Mouse Fab |
| HPAB-0204-YC-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0204-YC-F(E)) | ELISA, FC, RIA | Humanized Fab |
| HPAB-0440LY-F(E) | Human Anti-CLU Recombinant Antibody; Fab Fragment (HPAB-0440LY-F(E)) | ELISA, RIA, FC | Humanized Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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