Recombinant Mouse Anti-CPV Antibody (mAb16) (CAT#: PABW-140)

Recombinant Mouse Antibody (mAb16) is capable of binding to CPV, expressed in Chinese Hamster Ovary cells (CHO).


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ELISA

Figure 1 Antigenic analysis of capsids prepared as infectious viruses or expressed as empty capsids from expression plasmids.

Figure 1 Antigenic analysis of capsids prepared as infectious viruses or expressed as empty capsids from expression plasmids.

(B) ELISA results with CPV-d, A300D, G299E, and K387A and a subset of the MAbs shown in panel A. As shown previously, the filled squares indicate that the level of reaction was similar to that seen for CPV-d, hatched squares indicate ,10% the level of reaction to CPV-d at a dilution at which the reaction with CPV-d is .90% saturating, and open squares indicate no reaction
at any antibody dilution.

Parker, J. S., & Parrish, C. R. (1997). Canine parvovirus host range is determined by the specific conformation of an additional region of the capsid. Journal of Virology, 71(12), 9214-9222.

Neut

Figure 2 The neutralization of (A) CPV-2 and (B) FPV infectivity by various amounts of the IgGs of the 8 different MAb tested here.

Figure 2 The neutralization of (A) CPV-2 and (B) FPV infectivity by various amounts of the IgGs of the 8 different MAb tested here.

The IgGs were added to 10,000 TCID₅₀ of each virus at concentrations between 0 and 100 nM, incubated for 1 h at 37 °C, then the surviving virus was diluted and tested for surviving TCID50 in
CRFK cells. The results are shown as the surviving infectivity in each culture compared to the titer of the control virus. Bars show the standard error of the mean, comparing the results of 3 separate experiments done on separate days.

Nelson, C. D., Palermo, L. M., Hafenstein, S. L., & Parrish, C. R. (2007). Different mechanisms of antibody-mediated neutralization of parvoviruses revealed using the Fab fragments of monoclonal antibodies. Virology, 361(2), 283-293.


Specifications

  • Immunogen
  • CPV
  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • IgG
  • Specificity
  • Tested positive against native CPV
  • Species Reactivity
  • CPV
  • Clone
  • mAb16
  • Applications
  • Neut, ELISA

Product Property

  • Purity
  • >95% by SDS-PAGE and HPLC analysis
  • Storage
  • Store the antibody (in aliquots) at -20°C. Avoid repeated freezing and thawing of samples.

Applications

  • Application Notes
  • The CPV antibody has been reported in applications of Neutralization, Enzyme-linked Immunosorbent Assay.

Target

  • Alternative Names
  • CPV; Canine parvovirus

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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Recombinant Antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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