Products

Anti-CSPG4 immunotoxin (scFv)-Sap (AGTO-G013S)

This immunotoxin was achieved by conjugating/fusing the Anti-CSPG4 scFv to saporin. It was expressed in CHO and purified with affinity chromatography. The immunotoxin selectively binds to tumor cells and enters cells by receptor-mediated endocytosis. Upon release of the conjugate from endosomes, the saporin toxin catalytically renders the large subunit ribosomes unable to bind the elongation factors and inhibits protein synthesis. It was designed for treatment of glioblastoma multiforme (GBM).      

Specifications
Host
Mouse
Species Reactivity
Human
Molecule Class
scFv-Sap
Toxin Description
Saporin is a so-called ribosome inactivating protein (RIP), due to its N-glycosidase activity, from the seeds of Saponaria officinalis (common name: soapwort).Saporin depurinate the ribosomal RNA in a specific position; rendering the large subunit of ribosomes unable to bind the elongation factors. The consequent arrest of protein synthesis is responsible for the cytotoxicity.
Applications
This product is suitable for use in cytotoxicity assay, functional assay and immunotherapy.
Related Disease
glioblastoma multiforme (GBM)
Target
Alternative Names
CSPG4; chondroitin sulfate proteoglycan 4; NG2; MCSP; MCSPG; MSK16; HMW-MAA; MEL-CSPG
Entrez Gene ID
1464
UniProt ID
Q6UVK1

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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