Anti-CTLA4 ADCC Enhanced Antibody (JMW-3B3) is an ADCC enhanced antibody produced by our Afuco™ platform. This is a monoclonal antibody to investigate whether sCTLA-4 is important in controlling immune responses particularly in SLE patients. The anti-sCTLA-4 antibody is currently being humanised as a potential therapy for the treatment of some cancers.
Figure 1 Comparison of selective sCTLA-4 Ab with conventional anti-CTLA-4 mAb Ab blockade on PBMC effector T-cell responses.
(A) Dose–response effect of anti-sCTLA-4 mAb, JMW-3B3, on healthy donor resting PBMCs (left) is shown. Data are shown as mean + SEM of three replicates and are representative of three donors tested. Dose response effect of anti-sCTLA-4 mAb compared with four conventional "pan-specific" anti-CTLA-4 mAbs on healthy donor resting PBMCs is shown (right). Data are shown as mean + SEM of three replicates and are representative of three donors tested. (B) Summary comparison of anti-sCTLA-4 mAb with conventional anti-CTLA-4 mAb blockade (clone: BNI3) on PBMC responses from 10 donors. Left panels — resting cells with isotype Ab, anti-sCTLA-4 mAb, JMW3-B3, and anti-CTLA-4 mAb, BNI3; right panels — show data from cells stimulated with PPD (n = 10; **p < 0.01; *p < 0.05, ns: not significant, Wilcoxon).
Ward,F.J.,Dahal,L.N.,Wijesekera,S. K., Abdul-Jawad,S.K.,Kaewarpai,T.,Xu,H.,& Barker,R.N.(2013).The soluble isoform of CTLA-4 as a regulator of T-cell responses.European journal of immunology, 43(5), 1274-1285.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-067 | Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 - kappa |
TAB-206 | Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) | WB, IF, IP, Neut, FuncS, ELISA, FC | IgG2 |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-G015E | Anti-CTLA4 immunotoxin (scFv)-PE | Cytotoxicity assay, Function study | |
AGTO-G015S | Anti-CTLA4 immunotoxin (scFv)-Sap | Cytotoxicity assay, Function study | |
AGTO-G015M | Anti-CTLA4 immunotoxin (scFv)-Mel | Cytotoxicity assay, Function study |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-195CL | Mouse Anti-CTLA4 Recombinant Antibody (TAB-195CL) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-085MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
TAB-086MZ | Anti-Human CTLA4 Recombinant Antibody (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
TAB-085MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
TAB-085MZ-F(E) | Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2122.C) | ELISA, FC | Chimeric antibody (mouse/human) |
TAB-086MZ-F(E) | Anti-Human CTLA4 Recombinant Antibody Fab Fragment (TGN2422.C) | ELISA, FC | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-083MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2122.H) | ELISA, FC | Humanized antibody |
TAB-084MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (TGN2422.H) | ELISA, FC | Humanized antibody |
TAB-088MZ-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-088MZ-S(P)) | ELISA | Human scFv |
TAB-091MZ-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-091MZ-S(P)) | ELISA | Human scFv |
TAB-092MZ-S(P) | Human Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-092MZ-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-087MZ-S(P) | Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-087MZ-S(P)) | ELISA | Mouse scFv |
TAB-089MZ-S(P) | Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-089MZ-S(P)) | ELISA | Mouse scFv |
TAB-090MZ-S(P) | Mouse Anti-CTLA4 Recombinant Antibody; scFv Fragment (TAB-090MZ-S(P)) | ELISA | Mouse scFv |
TAB-093MZ-S(P) | Anti-Human CTLA4 Recombinant Antibody scFv Fragment (Mu-26B) | ELISA | |
MOB-0317MC | Recombinant Mouse Anti-CTLA4 Antibody | ELISA, FACS |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-567CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone 14D3) | FC, FuncS, Neut, IP, WB | Mouse IgG2a, κ |
NEUT-569CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone AS32) | WB, Neut | Mouse IgG1 |
NEUT-570CQ | Human Anti-CTLA4 Recombinant Antibody (clone YC030) | Neut | Human IgG1, κ |
NEUT-572CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone UC10-4B9) | FC, Block, ELISA, IP | Hamster IgG |
NEUT-573CQ | Rat Anti-Ctla4 Recombinant Antibody (clone 63828) | WB, FC, Neut | Rat IgG2a |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-568CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone L3D10) | FC, Block | Mouse IgG1, κ |
NEUT-571CQ | Mouse Anti-CTLA4 Recombinant Antibody (clone BN13) | Block, FC | Mouse IgG2a |
NEUT-577CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone MAB0835) | Block, FC | Hamster IgG |
NEUT-578CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone RYNmCTLA-4) | Block | Hamster IgG |
NEUT-579CQ | Hamster Anti-Ctla4 Recombinant Antibody (clone 9H10) | FC, Block | Hamster IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0855 | Hi-Affi™ Rabbit Anti-CTLA4 Recombinant Antibody (clone DS855AB) | WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0051-YC-F(E) | Human Anti-CTLA4 Recombinant Antibody (clone 10D1); Fab Fragment | ELISA, Cyt, Block | Human Fab |
HPAB-N0343-YC-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-N0343-YC-F(E)) | FC, ELISA | Human Fab |
HPAB-0749LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0749LY-F(E)) | FuncS, ELISA | Human Fab |
HPAB-0750LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0750LY-F(E)) | FuncS, ELISA | Human Fab |
HPAB-0751LY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-0751LY-F(E)) | FuncS, ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-006LC | Hamster Anti-Ctla4 Recombinant Antibody (clone YC082) | ELISA, FC | Hamster IgG |
MOB-061LC | Human Anti-CTLA4 Recombinant Antibody (MOB-061LC) | ELISA, WB, FuncS | Human IgG |
HPAB-N0343-YC | Human Anti-CTLA4 Recombinant Antibody (HPAB-N0343-YC) | FC, ELISA | Human IgG1, κ |
HPAB-0753LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0753LY) | FuncS, ELISA | Human IgG |
HPAB-0754LY | Human Anti-CTLA4 Recombinant Antibody (HPAB-0754LY) | FuncS, ELISA | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0477LY-S(P) | Human Anti-CTLA4 Recombinant Antibody (clone CBL007LY); scFv Fragment | Block, ELISA | Human scFv |
HPAB-0478LY-S(P) | Mouse Anti-CTLA4 Antibody scFv Fragment (HK44) | WB, FITC | scFv |
HPAB-N0054-YC-S(P) | Human Anti-CTLA4 Recombinant Antibody (clone 4H9-G5-D5-B1); scFv Fragment | ELISA, FC | Human scFv |
HPAB-1498-FY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1498-FY-F(E)) | ELISA | Human Fab |
HPAB-1499-FY-F(E) | Human Anti-CTLA4 Recombinant Antibody; Fab Fragment (HPAB-1499-FY-F(E)) | ELISA | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-067 | Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ipilimumab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-206 | Afuco™ Anti-CTLA4 ADCC Recombinant Antibody (Ticilimumab (= Tremelimumab)), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-AP860-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP860-YC) | ELISA, Block | Camel VHH |
HPAB-AP861-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP861-YC) | ELISA, Block | Camel VHH |
HPAB-AP862-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP862-YC) | ELISA, Block | Camel VHH |
HPAB-AP863-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP863-YC) | ELISA, Block | Camel VHH |
HPAB-AP864-YC | Camelid Anti-CTLA4 Recombinant Antibody; VHH Fragment (HPAB-AP864-YC) | ELISA, Block | Camel VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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