Anti-Human CXCL12 Recombinant Antibody (hu30D8) (CAT#: TAB-416CT)
Recombinant monoclonal antibody against mouse and human CXCL12α, CXCL12β, and CXCL12γ, was shown to dose-dependently block CXCL12α binding to CXCR4 and CXCR7, and CXCL12α-induced Jurkat cell migration in vitro.
Specific Inquiry
Funcs
Figure 1 In vivo activity of hu30D8.
Dose-dependent efficacy of hu30D8 in the human Calu-6 tumor model. Balb c/nude mice (n = 10/group) were treated with hu30D8 at various doses, alone) or with 30 mg/kg hu30D8 in combination with 10 mg/kg B20.4.1.1. Tumor size was measured at day 7, 10, 14, 17, and 21.
Zhong, C., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., ... & Quintana, L. (2013). Development and preclinical characterization of a humanized antibody targeting CXCL12. Clinical Cancer Research, 19(16), 4433-4445.
FACS
Figure 2 In vivo activity of hu30D8.
Percentage of F4/80+, CD11b+/Gr1+, and CD31+ cells in Calu6 tumors treated with the control human antibody or hu30D8 at day 21 after tumor cell implantation using FACS. Data are expressed as means ± SD and are representative of 3 independent experiments.
Zhong, C., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., ... & Quintana, L. (2013). Development and preclinical characterization of a humanized antibody targeting CXCL12. Clinical Cancer Research, 19(16), 4433-4445.
PK
Figure 3 Pharmacokinetic profiles of hu30D8.
hu30D8 e serum concentration–time profiles in cynomolgus monkeys after a single intravenous administration at 30 mg/kg (n = 5/group). Sera were collected for up to 10 days.
Zhong, C., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., ... & Quintana, L. (2013). Development and preclinical characterization of a humanized antibody targeting CXCL12. Clinical Cancer Research, 19(16), 4433-4445.
ELISA
Figure 4 Pharmacokinetic profiles of hu30D8.
hu30D8 serum concentration showed in and was measured by a specific ELISA using human CXCL12α as a coating agent.
Zhong, C., Wang, J., Li, B., Xiang, H., Ultsch, M., Coons, M., ... & Quintana, L. (2013). Development and preclinical characterization of a humanized antibody targeting CXCL12. Clinical Cancer Research, 19(16), 4433-4445.
Specifications
- Host Species
- Humanized
- Type
- Humanized antibody
- Specificity
- Human
- Species Reactivity
- Mouse and Human CXCL12α, CXCL12β, and CXCL12γ
- Clone
- hu30D8
- Applications
- Funcs, FC, PK, ELISA, Neut, WB
- Related Disease
- Cancer and inflammation-related diseases
Applications
- Application Notes
- The CXCL12 antibody has been reported in applications of Functional Assay, Flow Cytometry, Pharmacokinetic, Enzyme-linked Immunosorbent Assay, Neutralization, Western Blot.
Target
- Alternative Names
- CXCL12; chemokine (C-X-C motif) ligand 12; IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; stromal cell-derived factor 1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; anti-SDF-1
- Gene ID
- 6387
- UniProt ID
- P48061
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-F(E) | Recombinant Anti-human CXCL12 Antibody Fab Fragment | IF, FACS, FuncS | Fab |
| MHH-256-F(E) | Recombinant Human Anti-human CXCL12 Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
| PFBL-057 | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (PFBL-057) | FC, ELISA, FuncS | Human Fab |
| HPAB-0050LY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0050LY-F(E)) | Block, ELISA, WB, RIA, FC | Human Fab |
| HPAB-0051LY-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (HPAB-0051LY-F(E)) | Block, ELISA, WB, RIA, FC | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-256-S(P) | Recombinant Anti-human CXCL12 Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-256-S(P) | Recombinant Human Anti-human CXCL12 Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| HPAB-0050LY-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-0050LY-S(P)) | Block, ELISA, WB, RIA, FC | Human scFv |
| HPAB-632-FY-S(P) | Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-632-FY-S(P)) | Inhib | Mouse scFv |
| HPAB-633-FY-S(P) | Mouse Anti-CXCL12 Recombinant Antibody; scFv Fragment (HPAB-633-FY-S(P)) | Block | Mouse scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-040 | Recombinant Anti-Human CXCL12 VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| HPAB-0348-YC-VHH | Llama Anti-CXCL12 Recombinant Antibody; VHH Fragment (HPAB-0348-YC-VHH) | FuncS | Llama VHH |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-057 | Human Anti-CXCL12 Recombinant Antibody (PABL-057) | FC, ELISA, FuncS | Human IgG |
| MOB-1847CT | Recombinant Mouse anti-Human CXCL12 Monoclonal antibody (NN0322-0O37) | FC, IHC-P | |
| HPAB-0050LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0050LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0051LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0051LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
| HPAB-0052LY | Human Anti-CXCL12 Recombinant Antibody (HPAB-0052LY) | Block, ELISA, WB, RIA, FC | Human IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-415CT | Anti-Human CXCL12 Recombinant Antibody (30D8) | Inhib, WB, FC, Funcs, ELISA, Neut | |
| TAB-415CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (30D8) | WB, ELISA, Neut, FC | |
| TAB-415CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (30D8) | WB, ELISA, Neut, FC |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-416CT-S(P) | Anti-Human CXCL12 Recombinant Antibody scFv Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
| TAB-416CT-F(E) | Anti-Human CXCL12 Recombinant Antibody Fab Fragment (hu30D8) | WB, ELISA, Neut, FC | Humanized antibody |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-417CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-417CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-418CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-418CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-419CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-419CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-420CT-S(P) | Human Anti-CXCL12 Recombinant Antibody; scFv Fragment (TAB-420CT-S(P)) | BL, WB, ELISA | Human scFv |
| TAB-417CT-F(E) | Human Anti-CXCL12 Recombinant Antibody; Fab Fragment (TAB-417CT-F(E)) | BL, WB, ELISA | Human Fab |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-612CQ | Mouse Anti-CXCL12 Recombinant Antibody (clone CBL825) | Neut | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0884 | Hi-Affi™ Rabbit Anti-CXCL12 Recombinant Antibody (clone DS884AB) | WB, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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