Anti-Human CXCL13 Recombinant Antibody (MAb 5378) (CAT#: TAB-107MZ)

This antibody that specifically binds to CXCL13 may be used for treating autoimmune or inflammatory diseases, cancers, mucosa-associated lymphoid tissue (MALT) lymphomas, gastric or duodenal ulcers, as well as inhibiting gastric lymphoid follicles.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
ELISA

Figure 1 Epitope Competition ELISA results for MAb 5378, MAb 5261, and MAb 470.

Figure 1 Epitope Competition ELISA results for MAb 5378, MAb 5261, and MAb 470.

ELISA

Figure 2 Specificity ELISA results for MAb 5378, 3D2, and Mouse Isotype Control binding to recombinant human (A), cynomolgus monkey (B) and mouse (C) CXCL13.

Figure 2 Specificity ELISA results for MAb 5378, 3D2, and Mouse Isotype Control binding to recombinant human (A), cynomolgus monkey (B) and mouse (C) CXCL13.

Each data point represents mean of triplicate measurements. EC50 values were calculated from four-parameter sigmoidal curve fit (curves are shown on the graph; R for the curves that produced EC50 values were 0.99).

Inhib

Figure 3 Percent Inhibition of human pre-B-697-hCXCR5 (A), human tonsillar cells (B) and C57Black6 mouse spleenocyte (C) migration by MAb 5261 or MAb 5378 (A-B) and MAb 5378 or 3D2 (C).

Figure 3 Percent Inhibition of human pre-B-697-hCXCR5 (A), human tonsillar cells (B) and C57Black6 mouse spleenocyte (C) migration by MAb 5261 or MAb 5378 (A-B) and MAb 5378 or 3D2 (C).

Data represent an average of triplicate measurements +/- SEM from one of at least three experiments. Curves were fitted using four-parameter sigmoidal curve fit (curves are shown on the graph; R = 0.99).

Inhib

Figure 4 Percent Inhibition of human CXCL13-mediated internalization of human CXCR5 receptor by MAb 5378, MAb 5261, 3D2, Mouse Isotype Control, or Human Isotype Control.

Figure 4 Percent Inhibition of human CXCL13-mediated internalization of human CXCR5 receptor by MAb 5378, MAb 5261, 3D2, Mouse Isotype Control, or Human Isotype Control.

Data points for 5261 and 5378 represent average of measurements from two independent experiments. Data points for 3D2 and Isotype Controls represent average of triplicate measurements from a single experiment. Curve was fitted using four-parameter sigmoidal curve fit (curves are shown on the graph; R2 = 0.99). NE = no effect.

FuncS

Figure 5 Collagen-induced arthritis (CIA) disease progression in mice treated with MAb 5376, etanercept, or Mouse IgG (control) (CIA-1 Study).

Figure 5 Collagen-induced arthritis (CIA) disease progression in mice treated with MAb 5376, etanercept, or Mouse IgG (control) (CIA-1 Study).

Each data point represents a mean of scores taken from 10 mice. Group means were compared by using one-way ANOVA followed by Bonferroni's multiple comparison post test.

FuncS

Figure 6 Collagen-induced arthritis (CIA) disease progression in mice treated with MAb 5378, etanercept, MAb 470, or Mouse IgG (control) (CIA-2 Study).

Figure 6 Collagen-induced arthritis (CIA) disease progression in mice treated with MAb 5378, etanercept, MAb 470, or Mouse IgG (control) (CIA-2 Study).

Each data point represents a mean of scores taken from 10 mice. Group means were compared by using one-way ANOVA followed by Bonferroni's multiple comparison post test.


Specifications

  • Host Species
  • Human
  • Type
  • Humanized antibody
  • Specificity
  • Human
  • Species Reactivity
  • Mouse, Cynomolgus monkey
  • Clone
  • MAb 5378
  • Applications
  • ELISA, Inhib, FuncS
  • Related Disease
  • Autoimmune or inflammatory diseases, cancers, mucosa-associated lymphoid tissue (MALT) lymphomas, gastric or duodenal ulcers, and gastric lymphoid follicles.

Applications

  • Application Notes
  • The antibody was validated for ELISA, Inhibition, Function Assay. For details, refer to Published Data.

Target

  • Alternative Names
  • CXCL13; chemokine (C-X-C motif) ligand 13; BLC; BCA1; ANGIE; BCA-1; BLR1L; ANGIE2; SCYB13; C-X-C motif chemokine 13; CXC chemokine BLC; B-cell chemoattractant; B-lymphocyte chemoattractant; b lymphocyte chemoattractant; small-inducible cytokine B13; B-cell-attracting chemokine 1; b cell-attracting chemokine 1; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant)

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Recombinant Antibody

Chimeric Antibody

CAT Product Name Application Type
TAB-104MZ Anti-Human CXCL13 Recombinant Antibody (MAb 1476) ELISA Chimeric antibody (mouse/human)
TAB-104MZ-S(P) Anti-Human CXCL13 Recombinant Antibody scFv Fragment (MAb 1476) ELISA Chimeric antibody (mouse/human)
TAB-104MZ-F(E) Anti-Human CXCL13 Recombinant Antibody Fab Fragment (MAb 1476) ELISA Chimeric antibody (mouse/human)

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0149MZ Chicken Anti-CXCL13 Polyclonal IgY WB Chicken antibody

scFv Fragment Antibody

CAT Product Name Application Type
HPAB-0060-CN-S(P) Human Anti-CXCL13 Recombinant Antibody (clone Ab 1); scFv Fragment FC, ELISA, WB, IF Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
HPAB-0060-CN-F(E) Human Anti-CXCL13 Recombinant Antibody (clone Ab 1); Fab Fragment FC, ELISA, WB, IF Human Fab

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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