Anti-Human CXCR2 Recombinant Antibody (2B2) (CAT#: TAB-002MZ-VHH)

This antibody specifically binding to chemokine receptor CXCR2 may be used for treatment of diseases involving aberrant functioning of CXCR2.


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Inhib

Figure 1 Inhibition of FLAG-tagged sdAb binding to CHO-CXCR2 cells by monovalent sdAbs using FLAG-tagged 163E3 and using
FLAG-tagged 127D1.

Figure 1 Inhibition of FLAG-tagged sdAb binding to CHO-CXCR2 cells by monovalent sdAbs using FLAG-tagged 163E3 and using FLAG-tagged 127D1.

Competition experiments using a representative FLAGtagged monovalent sdAb from each class (127D1 for class 1 and 163E3 for class 2) showed that sdAbs within the same class compete with each other, whereas sdAbs from different classes do not compete with each other.

Bradley, M. E., Dombrecht, B., Manini, J., Willis, J., Vlerick, D., De Taeye, S., ... & Laeremans, T. (2015). Potent and efficacious inhibition of CXCR2 signaling by biparatopic sdAbs combining two distinct modes of action. Molecular pharmacology, 87(2), 251-262.


Specifications

  • Host Species
  • Human
  • Type
  • Single domain antibody
  • Specificity
  • Human
  • Clone
  • 2B2
  • Applications
  • FC, Inhib
  • Related Disease
  • Chronic obstructive pulmonary disease (COPD)

Applications

  • Application Notes
  • The antibody was validated for Inhibition. For details, refer to Published Data.

Target

  • Alternative Names
  • CXCR2; chemokine (C-X-C motif) receptor 2; CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b; C-X-C chemokine receptor type 2; CXC-R2; CXCR-2; IL-8R B; GRO/MGSA receptor; IL-8 receptor type 2; interleukin 8 receptor B; chemokine (CXC) receptor 2; interleukin 8 receptor, beta; interleukin 8 receptor type 2; interleukin-8 receptor type B; CXCR2 gene for IL8 receptor type B; high affinity interleukin-8 receptor B

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "CXCR2"

Single-domain Antibody

CAT Product Name Application Type
NABG-050 Recombinant Anti-Human CXCR2 VHH Single Domain Antibody ELISA, IHC, FC, FuncS Llama VHH
TAB-004MZ-VHH Anti-Human CXCR2 Recombinant Antibody (54B12) ELISA, IHC, FuncS, SPR Single domain antibody

Recombinant Antibody

CAT Product Name Application Type
MOB-2067MZ Recombinant Mouse Anti-Human CXCR2 Antibody (clone 20) ELISA, ELISA, FC, IHC-P, WB Mouse antibody
HPAB-0306-YC Human Anti-CXCR2 Recombinant Antibody (clone HY29) ELISA, FC, FuncS Humanized IgG1
HPAB-0417-CN Human Anti-CXCR2 Recombinant Antibody (clone ZY05KA-G08) ELISA Chimeric (mouse/human) IgG
VS-0723-WK66 Human Anti-CXCR2 Recombinant Antibody (VS-0723-WK66) FC Chimeric (rabbit/human) IgG1

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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