Anti-Human CXCR4 Recombinant Antibody (6C7) (CAT#: TAB-154MZ)

This antibody that specifically binds to CXCR4 and inhibits the biological activity of CXCR4 may be useful for diagnostics and treatment of diseases associated with the activity and expression of CXCR4.


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  • Published Data
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  • Datasheet
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Inhib

Figure 1 shows line graphs representing dose-response curves for various antibodies in inhibition of Jurkat cell chemotaxis.

Figure 1 shows line graphs representing dose-response curves for various antibodies in inhibition of Jurkat cell chemotaxis.

Inhib

Figure 2 depicts inhibitory activity of antibody 6C7 in U937 (2A) and HSC-F (2B) chemotaxis assays.

Figure 2 depicts inhibitory activity of antibody 6C7 in U937 (2A) and HSC-F (2B) chemotaxis assays.

Block

Figure 3 shows the results demonstrating blocking of labeled SDF-1 binding to Namalwa cells by antibody 6C7.

Figure 3 shows the results demonstrating blocking of labeled SDF-1 binding to Namalwa cells by antibody 6C7.

Block

Figure 4 provides line graphs depicting Kinexa analysis of on-cell affinity of antibodies to human CXCR4 on Namalwa cells.

Figure 4 provides line graphs depicting Kinexa analysis of on-cell affinity of antibodies to human CXCR4 on Namalwa cells.

FuncS

Figure 5 is a bar chart shows induction of apoptosis by various antibodies in Ramos cells.

Figure 5 is a bar chart shows induction of apoptosis by various antibodies in Ramos cells.

FuncS

Figure 6 depicts the results of experiments evaluating the activity of an anti-CXCR4 antibody of the disclosure in a model of ovarian cancer.

Figure 6 depicts the results of experiments evaluating the activity of an anti-CXCR4 antibody of the disclosure in a model of ovarian cancer.

FuncS

Figure 7 depicts the results of experiments evaluating the effects of an anti-CXCR4 antibody of the disclosure in a chronic lymphocytic leukemia (CLL) model.

Figure 7 depicts the results of experiments evaluating the effects of an anti-CXCR4 antibody of the disclosure in a chronic lymphocytic leukemia (CLL) model.


Specifications

  • Immunogen
  • Chinese Hamster Ovary (CHO) cells transiently transfected with human CXCR4
  • Host Species
  • Human
  • Type
  • Human antibody
  • Specificity
  • Human
  • Species Reactivity
  • Cynomolgus
  • Clone
  • 6C7
  • Applications
  • Block, FuncS, Inhib
  • Related Disease
  • CXCR4 mediated diseases such as CXCR4 positive tumors

Applications

  • Application Notes
  • This antibody has been reported for use in Blocking, Functional Assay, Inhibition.

Target

  • Alternative Names
  • CXCR4; chemokine (C-X-C motif) receptor 4; FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; HSY3RR; NPYY3R; D2S201E; C-X-C chemokine receptor type 4; fusin; CD184 antigen; SDF-1 receptor; LPS-associated protein 3; neuropeptide Y receptor Y3; seven transmembrane helix receptor; stromal cell-derived factor 1 receptor; lipopolysaccharide-associated protein 3; seven-transmembrane-segment receptor, spleen; leukocyte-derived seven transmembrane domain receptor

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone 6C7"

See other products for "CXCR4"

Chicken IgY Antibody

CAT Product Name Application Type
BRD-0152MZ Chicken Anti-CXCR4 Polyclonal IgY WB Chicken antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-686CQ Mouse Anti-CXCR4 Recombinant Antibody (clone 44716.111) FC, ICC, IF, IHC-P, Inhib Mouse IgG2b

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-0889 Hi-Affi™ Rabbit Anti-CXCR4 Recombinant Antibody (clone DS889AB) WB, IHC Rabbit IgG

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-H72 Afuco™ Anti-CXCR4 ADCC Recombinant Antibody (Ulocuplumab), ADCC Enhanced IP, IF, FuncS, FC, Neut, ELISA ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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