Mouse Anti-DDR1 Recombinant Antibody (clone 3E10) (CAT#: PABC-152)
Recombinant Mouse Antibody (3E10) is capable of binding to DDR1, expressed in Chinese Hamster Ovary cells (CHO). The antibody likely inhibit signaling by sterically blocking the extracellular association of DDR1 subunits.
Specific Inquiry
IF
Figure 1 3E10 scFv proteins that do not bind DNA still inhibit HDR.
Primary broblasts were transfected with the 2XMBP-scFv expression con-structs. Cellular expression of each scFv was verified via immunofluorescence.
Turchick, A., Hegan, D. C., Jensen, R. B., & Glazer, P. M. (2017). A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic acids research, 45(20), 11782-11799.
Inhib
Figure 2 3E10 inhibits RAD51 binding to DNA and RAD51-mediated strand exchange.
Scheme of RAD51 DNA binding assay performed withpre-incubation of RAD51 and 2XMBP-scFv proteins.
Turchick, A., Hegan, D. C., Jensen, R. B., & Glazer, P. M. (2017). A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic acids research, 45(20), 11782-11799.
IF
Figure 3 3E10 inhibits RAD51 nuclear localization and foci formation after irradiation.
Representative images of treated primary skin fibroblasts.
Turchick, A., Hegan, D. C., Jensen, R. B., & Glazer, P. M. (2017). A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic acids research, 45(20), 11782-11799.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human DDR1
- Species Reactivity
- Human
- Clone
- 3E10
- Applications
- Neut, ELISA
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Immunofluorescence and Inhibition.
Target
- Alternative Names
- DDR1; discoidin domain receptor tyrosine kinase 1; CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A; epithelial discoidin domain-containing receptor 1; tyrosine kinase DDR; cell adhesion kinase; mammary carcinoma kinase 10; tyrosine-protein kinase CAK; protein-tyrosine kinase RTK-6; neuroepithelial tyrosine kinase; PTK3A protein tyrosine kinase 3A; CD167 antigen-like family member A; neurotrophic tyrosine kinase, receptor, type 4
- Gene ID
- 780
- UniProt ID
- Q08345
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-152 | Mouse Anti-DDR1 Recombinant Antibody (clone 3E10); Fab Fragment | Neut, ELISA | Mouse Fab |
| HPAB-0077-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05570); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0078-CN-S(P) | Human Anti-DDR1 Recombinant Antibody (clone APE05571); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0061-LSX-S(P) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0125-YJ-S(P) | Human Anti-DDR1 Recombinant Antibody (clone CBD02YJ); scFv Fragment | FC, ELISA, Inhib | Human scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-176MZ | Anti-Human DDR1 Recombinant Antibody (DDR1-ab1) | FuncS | Human antibody |
| TAB-177MZ | Anti-Human DDR1 Recombinant Antibody (DDR1-ab2) | FuncS | Human antibody |
| TAB-176MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab1) | IF | Human antibody |
| TAB-177MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab2) | IF | Human antibody |
| TAB-178MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (DDR1-ab3) | IF | Human antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (AB2004) | ELISA | |
| TAB-180MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (AB2009) | ELISA | |
| TAB-181MZ-F(E) | Anti-Human DDR1 Recombinant Antibody Fab Fragment (AB2041) | ELISA | |
| TAB-182MZ-F(E) | Mouse Anti-DDR1 Recombinant Antibody; Fab Fragment (TAB-182MZ-F(E)) | FC | Mouse Fab |
| PABX-043 | Recombinant Mouse Anti-DDR1 Antibody (3E3) | WB, Neut, FuncS, ELISA, Block | IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1224CT | Recombinant Mouse anti-Human DDR1 Monoclonal antibody (3H5F23) | ELISA, IHC-P, WB | |
| HPAB-0061-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026) | ELISA | Mouse IgG |
| HPAB-0062-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039) | ELISA | Mouse IgG |
| HPAB-0063-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031) | ELISA | Mouse IgG |
| HPAB-0064-LSX | Mouse Anti-DDR1 Recombinant Antibody (clone AB2074) | ELISA | Mouse IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0953 | Hi-Affi™ Rabbit Anti-DDR1 Recombinant Antibody (clone DS953AB) | ELISA, WB | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0077-CN-F(E) | Human Anti-DDR1 Recombinant Antibody (clone APE05570); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0078-CN-F(E) | Human Anti-DDR1 Recombinant Antibody (clone APE05571); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0061-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2026); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0062-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2039); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0063-LSX-F(E) | Mouse Anti-DDR1 Recombinant Antibody (clone AB2031); Fab Fragment | ELISA | Mouse Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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