This antibody, specific for Dkk-1, can be potentially used as an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway for treating bone disorders which results in a loss in bone, for example, osteoporosis.
Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.
Figure 2 shows the result for RH2-18 antibodies retitrated using an extended dose range. The results shows that for this assay format the RH2-18 antibodies had an effective dose of about 5 nM.
Figure 3 shows that distal femur bone mineral density (BMD) was increased 5.2 to 8.7% in a dose effect fashion by RH2-18 antibodies in the dose range 0.5 to 5 mg/kg. Error bars = SEM. N=I l /group.
Figure 4 shows a xenograph model for tumor growth and the effect of the antibody on tumor growth.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-192MZ | Anti-Mouse DKK1 Recombinant Antibody (JC18) | ELISA, FuncS | |
TAB-194MZ | Mouse Anti-DKK1 Recombinant Antibody (TAB-194MZ) | ELISA | Mouse IgG |
TAB-192MZ-F(E) | Anti-Mouse DKK1 Recombinant Antibody Fab Fragment (JC18) | ELISA | |
TAB-194MZ-F(E) | Mouse Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-194MZ-F(E)) | ELISA | Mouse Fab |
TAB-196MZ-F(E) | Rat Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-196MZ-F(E)) | ELISA | Rat Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-193MZ | Anti-Human DKK1 Recombinant Antibody (huMabJC18) | ELISA | Humanized antibody |
TAB-193MZ-S(P) | Anti-Human DKK1 Recombinant Antibody scFv Fragment (huMabJC18) | ELISA | Humanized antibody |
TAB-193MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (huMabJC18) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-195MZ-F(E) | Human Anti-DKK1 Recombinant Antibody; Fab Fragment (TAB-195MZ-F(E)) | In vivo efficacy assay | Human Fab |
TAB-197MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH1-10) | WB | Human antibody |
TAB-198MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-18) | WB | Human antibody |
TAB-199MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-31) | WB | Human antibody |
TAB-200MZ-F(E) | Anti-Human DKK1 Recombinant Antibody Fab Fragment (RH2-59) | WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-010MZ-VHH | Anti-Human DKK1 Recombinant Antibody (1B9) | ELISA | Single domain antibody |
TAB-011MZ-VHH | Anti-Human DKK1 Recombinant Antibody (4E4) | ELISA | Single domain antibody |
TAB-012MZ-VHH | Anti-Human DKK1 Recombinant Antibody (16A12) | ELISA | Single domain antibody |
TAB-013MZ-VHH | Anti-Human DKK1 Recombinant Antibody (4E4hum 7) | ELISA | Single domain antibody |
HPAB-1510-FY | Llama Anti-DKK1 Recombinant Antibody (HPAB-1510-FY) | ELISA | Llama VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-703CQ | Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) | Neut | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-0991 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone DS991AB) | FC, ICC, IF, IHC-P, WB | Rabbit IgG |
MOR-4137 | Hi-Affi™ Rabbit Anti-DKK1 Recombinant Antibody (clone SI210DS) | Neut | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0278-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0278-YC-S(P)) | ELISA, Block, FuncS | Human scFv |
HPAB-0279-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0279-YC-S(P)) | Block, FuncS | Human scFv |
HPAB-0280-YC-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0280-YC-S(P)) | ELISA | Human scFv |
HPAB-0096-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0096-FY-S(P)) | FuncS | Human scFv |
HPAB-670-FY-S(P) | Human Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-670-FY-S(P)) | ELISA | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0096-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-0096-FY) | FuncS | Human IgG, κ |
HPAB-0107-FY | Human Anti-DKK1 Recombinant Antibody (HPAB-0107-FY) | FuncS | Human IgG, λ |
MRO-0479-CN | Rabbit Anti-DKK1 Recombinant Antibody (clone CBACN-197) | WB, IF, IHC, FC | Rabbit IgG |
MRO-1816-CN | Rabbit Anti-DKK1 Polyclonal Antibody (MRO-1816-CN) | WB, IF, IHC, FC | Rabbit IgG |
HPAB-0757-FY | Mouse Anti-DKK1 Recombinant Antibody (HPAB-0757-FY) | ELISA | Mouse IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0757-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0757-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0758-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0758-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0759-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0759-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0760-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0760-FY-S(P)) | ELISA | Mouse scFv |
HPAB-0761-FY-S(P) | Mouse Anti-DKK1 Recombinant Antibody; scFv Fragment (HPAB-0761-FY-S(P)) | ELISA | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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