Anti-Human DKK1 Recombinant Antibody (RH2-18) (CAT#: TAB-198MZ)

This antibody, specific for Dkk-1, can be potentially used as an inhibitor of the osteoanabolic Wnt/LRP5 signaling pathway for treating bone disorders which results in a loss in bone, for example, osteoporosis.


Specific Inquiry
  • Size:
  • Conjugation:
  • Endotoxin:
  • Purity:
  • Fc Engineering:
  • Published Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Inhib

Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.

Figure 1 shows Eu-Dkk-1 binding to HEK293hLrp5 cells and inhibitory activity of anti-Dkk-1 antibodies RH2-10, RH2-18, RH2-31, RH2-59, and RH2-80 at various concentrations.

ELISA

Figure 2 shows the result for RH2-18 antibodies retitrated using an extended dose range. The results shows that for this assay format the RH2-18 antibodies had an effective dose of about 5 nM.

Figure 2 shows the result for RH2-18 antibodies retitrated using an extended dose range. The results shows that for this assay format the RH2-18 antibodies had an effective dose of about 5 nM.

FuncS

Figure 3 shows that distal femur bone mineral density (BMD) was increased 5.2 to 8.7% in a dose effect fashion by RH2-18 antibodies in the dose range 0.5 to 5 mg/kg. Error bars = SEM. N=I l /group.

Figure 3 shows that distal femur bone mineral density (BMD) was increased 5.2 to 8.7% in a dose effect fashion by RH2-18 antibodies in the dose range 0.5 to 5 mg/kg. Error bars = SEM. N=I l /group.

FuncS

Figure 4 shows a xenograph model for tumor growth and the effect of the antibody on tumor growth.

Figure 4 shows a xenograph model for tumor growth and the effect of the antibody on tumor growth.


Specifications

  • Host Species
  • Human
  • Derivation
  • Human phage display library
  • Type
  • Human antibody
  • Specificity
  • Human
  • Clone
  • RH2-18
  • Applications
  • ELISA, FuncS, Inhib
  • Related Disease
  • A loss in bone, such as osteoporosis

Applications

  • Application Notes
  • This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Functional Assay, Inhibition.

Target

  • Alternative Names
  • DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1

Related Resources

  • Related Signaling Pathways

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone RH2-18"

See other products for "DKK1"

Single-domain Antibody

Neutralizing Antibody

CAT Product Name Application Type
NEUT-703CQ Rabbit Anti-DKK1 Recombinant Antibody (clone CBL1003) Neut Rabbit IgG

Rabbit Monoclonal Antibody

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for TAB-198MZ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare