Human Anti-DLL4 Recombinant Antibody (TAB-218MZ) (CAT#: TAB-218MZ)
This recombinant human antibody is a novel monoclonal antibody that binds specifically to delta-like ligand (DLL4). The antibody was purified by affinity chromatography. It can be used for ELISA, FC, Neut and other applications. The antibody inhibits the growth of cancer cells by inhibiting the interaction between DLL4 ligand and Notch. The IC₅₀ value of decreasing human DLL4-His bound to Notch 1-Fc is 1.32 nM.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human small intestine
(Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg
(Immunohistochemical staining of human small intestine shows strong membranous positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_2_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_9_3.jpg
Figure 3 Liver
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg
(Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_4.jpg
Figure 4 Kidney
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg
(Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_8_5.jpg
Figure 5 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/23392/51479_A_4_6.jpg
Figure 6 RNA cell line category: Group enriched (BJ hTERT+, HUVEC TERT2, SCLC-21H)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128917-DLL4
Specifications
- Immunogen
- Human DLL4 protein
- Host Species
- Human
- Derivation
- Phage display library
- Type
- Human IgG
- Specificity
- Human
- Species Reactivity
- Human
- Applications
- ELISA, FC, Neut
- Related Disease
- Rheumatoid arthritis, systemic sclerosis, systemic Lupus erythematosus, atopic dermatitis, and the like
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- DLL4; delta-like 4 (Drosophila); hdelta2; delta-like protein 4; delta4; delta 4; delta ligand 4; notch ligand DLL4; delta-like 4 homolog; delta-like 4 protein; notch ligand delta-2; drosophila Delta homolog 4
- Gene ID
- 54567
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "DLL4"
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-204 | Anti-Human DLL4 Recombinant Antibody (Demcizumab) | ELISA, FC, IP, FuncS, IF, Neut, WB | IgG2 - kappa |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-744 | Anti-DLL4 Recombinant Antibody | WB, Neut, ELISA, IF, IP, FuncS, FC | IgG1 - kappa |
| TAB-219MZ | Human Anti-DLL4 Recombinant Antibody (TAB-219MZ) | ELISA, FC, Neut, WB | Human IgG |
| TAB-220MZ | Human Anti-DLL4 Recombinant Antibody (TAB-220MZ) | ELISA, FC, Neut | Human IgG |
| TAB-221MZ | Human Anti-DLL4 Recombinant Antibody (TAB-221MZ) | ELISA, FC, Neut | Human IgG |
| TAB-222MZ | Human Anti-DLL4 Recombinant Antibody (TAB-222MZ) | Block, FC, FuncS, Inhib | Human IgG |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-217CL | Human Anti-DLL4 Recombinant Antibody (TAB-217CL) | WB, IHC, IF, FC, Inhib | Human IgG |
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-217MZ | Human Anti-DLL4 Recombinant Antibody (TAB-217MZ) | FC, FuncS | Chimeric (mouse/human) IgG |
| TAB-217MZ-S(P) | Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-217MZ-S(P)) | FC | Mouse scFv |
| TAB-217MZ-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-217MZ-F(E)) | FC | Chimeric antibody (mouse/human) |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-216MZ-S(P) | Mouse Anti-DLL4 Recombinant Antibody; scFv Fragment (TAB-216MZ-S(P)) | FC | Mouse scFv |
| TAB-227MZ-F(E) | Anti-Human DLL4 Recombinant Antibody Fab Fragment (1C1) | ELISA, FC | |
| TAB-232MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-232MZ-F(E)) | ELISA, FC | Rat Fab |
| TAB-233MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-233MZ-F(E)) | ELISA, FC | Rat Fab |
| TAB-234MZ-F(E) | Rat Anti-DLL4 Recombinant Antibody; Fab Fragment (TAB-234MZ-F(E)) | ELISA, FC | Rat Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0202CT | Recombinant Mouse anti-Human DLL4 Monoclonal antibody (4A11) | ELISA, FC, WB | |
| HPAB-0156CQ | Human Anti-DLL4 Recombinant Antibody (clone YW26.82) | ELISA, FC, IHC, Block | Human IgG1, κ |
| MRO-1817-CN | Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1817-CN) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-1818-CN | Rabbit Anti-DLL4 Polyclonal Antibody (MRO-1818-CN) | WB, IF, IHC, FC | Rabbit IgG |
| FN-220CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-1) | FC, FuncS, IF | Hamster IgG |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-707CQ | Hamster Anti-Dll4 Recombinant Antibody (clone HMD4-2) | Block | Hamster IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4140 | Hi-Affi™ Rabbit Anti-DLL4 Recombinant Antibody (clone SI213DS) | ELISA | Rabbit IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0203-CN-S(P)) | ELISA, WB, FC, IP | Human scFv |
| HPAB-0204-CN-S(P) | Human Anti-DLL4 Recombinant Antibody; scFv Fragment (HPAB-0204-CN-S(P)) | ELISA, WB, FC, IP | Human scFv |
| HPAB-0716-FY-F(E) | Mouse Anti-DLL4 Recombinant Antibody (clone AB015); scFv Fragment | FC | Mouse scFv |
| HPAB-1108-FY-F(E) | Human Anti-DLL4 Recombinant Antibody (clone 61B); scFv Fragment | ELISA | Human scFv |
| HPAB-1109-FY-F(E) | Human Anti-DLL4 Recombinant Antibody (clone 2-6); scFv Fragment | ELISA | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0203-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0203-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0204-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0204-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0205-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0205-CN-F(E)) | ELISA, WB, FC, IP | Human Fab |
| HPAB-0206-CN-F(E) | Mouse Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0206-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Mouse Fab |
| HPAB-0208-CN-F(E) | Human Anti-DLL4 Recombinant Antibody; Fab Fragment (HPAB-0208-CN-F(E)) | ELISA, WB, FC, IHC, IF, ICC | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-204 | Afuco™ Anti-DLL4 ADCC Recombinant Antibody (Demcizumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1512-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56A09) | Block, ELISA, FC | Llama VHH |
| HPAB-1513-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (56H08) | Block, ELISA, FC | Llama VHH |
| HPAB-1514-FY | Recombinant Llama Anti-DLL4 Single Domain Antibody (104G01) | Block, ELISA, FC | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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