Products

Anti-DNA Immunocytokine, IgG (TNT)-IL2 (ACFP-SH062)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-DNA IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the DNA as well as the biological activity of IL2. The IL2 can specifically reach tumor parts, and can be used for reversing the local immunosuppression state of tumors and activating part bodies and integral antitumor immunity. This immunocytokine was designed for treating melanoma or lung cancer or other solid tumors.      

Specifications
Target
DNA
Molecule Class
L Kappa; IgG1-IL2
Species Reactivity
Human
Host
Humanized from Mouse
Expression Host
CHO
Clone
TNT
Related Disease
Melanoma or lung cancer or other solid tumors
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
Deoxyribonucleic acid; ss DNA

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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