Anti-DNA Antibody-Cytokine Fusion Protein, IgG (chTNT-3)-IFNγ (CAT#: ACFP-SH138)
This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-DNA IgG to IFNγ. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the DNA as well as the biological activity of IFNγ. The chTNT3/muIFN-γ can safely target syngeneic tumor models as part of a promising strategy for the targeted immunotherapy of solid tumors. This immunocytokine was designed for treating tumor.
Specific Inquiry
Specifications
- Target
- DNA
- Molecule Class
- IgG-IFNγ
- Species Reactivity
- Human
- Expression Host
- CHO
- Clone
- chTNT-3
- Related Disease
- Tumor
- Cytokine 1
- IFNγ
- Cytokines 1 Description
- Interferon gamma (IFNγ) is a dimerized soluble cytokine that is the only member of the type II class ofinterferons. The existence of this interferon, which early in its history was known as immune interferon, was described by E. F. Wheelock as a product of human leukocytes stimulated with phytohemagglutinin, and by others as a product of antigen-stimulated lymphocytes or tuberculin-sensitized mouse peritoneal lymphocytes challenged with PPD; the resulting supernatants were shown to inhibit growth of vesicular stomatitis virus. Those reports also contained the basic observation underlying the now widely employed interferon gamma release assay used to test for tuberculosis. In humans, the IFNγ protein is encoded by the IFNG gene.
- Cytokine 1 Species
- Mouse
- Applications
- This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
- Alternative Names
- Deoxyribonucleic acid; ss DNA
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABW-032 | Recombinant Mouse Anti-DNA Antibody (ED10) | WB, ELISA | IgG |
| PABC-033 | Mouse Anti-DNA Recombinant Antibody (clone 64M-2) | ELISA, WB | Mouse IgG |
| FAMAB-0093CQ | Mouse Anti-DNA Recombinant Antibody (clone DP17) | ELISA | Mouse IgG1 |
| FAMAB-0094CQ | Mouse Anti-DNA Recombinant Antibody (clone F2-2) | ELISA | Mouse IgG2a, κ |
| FAMAB-0095CQ | Mouse Anti-DNA Recombinant Antibody (clone H241) | ELISA | Mouse IgG |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-048 | Recombinant Mouse Anti-DNA Antibody | WB, ELISA, FuncS | IgG |
| PABX-048-F (E) | Recombinant Mouse Anti-DNA Antibody Fab Fragment | WB, ELISA, FuncS | Fab |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-048-S (P) | Recombinant Mouse Anti-DNA Antibody scFv Fragment | WB, ELISA, FuncS | scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0086-YC-F(E) | Mouse Anti-DNA Recombinant Antibody (clone H149); Fab Fragment | ELISA, IF | Mouse Fab |
| FAMAB-0087-YC-F(E) | Mouse Anti-DNA Recombinant Antibody (clone F11); Fab Fragment | ELISA, IF | Mouse Fab |
| FAMAB-0088-YC-F(E) | Mouse Anti-DNA Recombinant Antibody (clone 17s.128); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0089-YC-F(E) | Mouse Anti-DNA Recombinant Antibody (clone PL9-6); Fab Fragment | ELISA, IF | Mouse Fab |
| FAMAB-0090-YC-F(E) | Mouse Anti-DNA Recombinant Antibody (clone PL9-11); Fab Fragment | ELISA, IF | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0034WJ-S(P) | Human Anti-DNA Recombinant Antibody (clone T33-4); scFv Fragment | WB | Human scFv |
| FAMAB-0035WJ-S(P) | Human Anti-DNA Recombinant Antibody (clone T33-16); scFv Fragment | WB | Human scFv |
| FAMAB-0036WJ-S(P) | Human Anti-DNA Recombinant Antibody (clone T33-17); scFv Fragment | WB | Human scFv |
| FAMAB-0046WJ-S(P) | Human Anti-DNA Recombinant Antibody (clone O-81); scFv Fragment | WB | Human scFv |
| FAMAB-0067WJ-S(P) | Human Anti-DNA Recombinant Antibody (clone D2C10); scFv Fragment | WB | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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