Products

Anti-E. coli Etk Intrabody [(D-Arg)9] (IAB-B062(A))

Recombinant anti-E. coli Etk intrabody linked to (D-Arg)9 works within cells to bind E. coli Etk, expressed in E. coli cells. The intrabody is specific for the kinase domain of Etk and reduces or inhibits autophosphorylation or phosphorylation of a substrate.      

Specifications
Immunogen
Escherichia coli tyrosine-protein kinase, role in O-antigen capsule formation
Host
human
Type
scFv-(D-Arg)9
Cell Penetrating Peptide
(D-Arg)9
It has been proven that polyarginine peptides composed of nine arginine amino acids (Arg-9) are able to translocate across cells very efficiently. This raises the question if molecular dynamics simulations would show a similar pathway for this highly hydrophilic and charged peptide as predicted for the Tat peptide. The simplicity of Arg-9 over other CPPs also helps isolate the role of the Arg sidechain on the translocation without the effect of other sidechains. Therefore, in this work we study computationally the translocation of Arg-9 through a lipid bilayer and show that the translocation mechanism is the same as for the Tat peptide.
Species Reactivity
E. coli
Applications
Products can be used for: Western blot; Coimmunopricipation; Functional studies
Target
Alternative Names
E. coli Etk; Escherichia coli tyrosine-protein kinase, role in O-antigen capsule formation
Entrez Gene ID
947409

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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