Products

Anti-EDA Immunocytokine, IgG (F8)-IL10 (ACFP-SH096)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA IgG to IL10. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL10. In the cardiac allografts, treatment with F8-ratIL10 was associated with increased heart weights, a higher grade of chronic rejection, increased CIF, higher protein expression levels of alpha-smooth muscle actin (α-SMA), an augmented infiltration with inflammatory cells (CD4 +, CD8 + and CD68 + cells) and higher serum levels of brain natriuretic peptide (BNP) compared to the control groups. This immunocytokine was designed for treating melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
IgG-IL10
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL10
Cytokines 1 Description
Viral interleukin-10 has now been termed viral interleukin 10 (vlL-10) to reflect its protein sequence homology to "cellular" IL10 (cIL10, either murine or human IL10). It is now widely accepted that vlL-10 shares many functions with clL-10, principally, the ability to enhance survival of newly infected B cells and to diminish the production of IFN-β and IL-2 during ongoing immune reactions.
Cytokine 1 Species
Rat
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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