Products

Anti-EDA Immunocytokine, IgG (F8)-IL1b (ACFP-SH103)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA IgG to IL1b. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL1b. The IL1b fusion exhibited lower tumor to organ ratios and a slower blood clearance profile. This immunocytokine was designed for treating melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
IgG-IL1b
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL1b
Cytokines 1 Description
Interleukin 1 beta (IL1β) also known as '"leukocytic pyrogen"', "'leukocytic endogenous mediator'", "'mononuclear cell factor'", "'lymphocyte activating factor'" and other names, is a cytokine protein that in humans is encoded by the IL1B gene. There are two genes for Interleukin-1 (IL-1) : IL-1 alpha and IL-1 beta (this gene). IL-1β precursor is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase) to form mature IL-1β.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Send Inquiry Now!
Name:
* Phone:
* E-mail Address:
* Service & Products Interested:
Project Description:
* Verification Code:
Please input "biolabs"(case insensitive) as verification code.
Contact Us to Order
Tel: 1-631-871-5806
Fax: 1-631-207-8356
Email:

45-1 Ramsey Road, Shirley, NY 11967, USA     Tel: 1-631-871-5806    Fax: 1-631-207-8356    Email:
Terms of Service-Privacy Policy     © 2007 - 2017 Creative-Biolabs All Rights Reserved