Products

Anti-EDA Immunocytokine, scFv (F8)-IL10 (ACFP-SH095)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA scFv to IL10. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL10. For this fusion protein, a selective targeting of arthritic lesions and neovascular tumor structures in mice was observed. In a collagen-induced arthritis model in mice, F8-IL10 was also able to inhibit progression of established arthritis alone or in combination with methotrexate. In a further study, the F8-IL10 fusion protein was investigated for the treatment of endometriosis, which is characterized by extrauterine growth of endometrium-like tissue accompanied by angiogenesis. This immunocytokine was designed for treating endometriosis, melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
scFv-IL10
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Endometriosis, Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL10
Cytokines 1 Description
Viral interleukin-10 has now been termed viral interleukin 10 (vlL-10) to reflect its protein sequence homology to "cellular" IL10 (cIL10, either murine or human IL10). It is now widely accepted that vlL-10 shares many functions with clL-10, principally, the ability to enhance survival of newly infected B cells and to diminish the production of IFN-β and IL-2 during ongoing immune reactions.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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