Products

Anti-EDA Immunocytokine, scFv (F8)-IL2 (ACFP-SH105)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA scFv to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL2. The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma. This immunocytokine was designed for treating melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
scFv-IL2
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL2
Cytokines 1 Description
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a protein that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity. IL-2 is part of the body's natural response to microbial infection, and in discriminating between foreign ("non-self") and "self". IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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