Products

Anti-EDA Immunocytokine, scFv (F8)-IL6 (ACFP-SH109)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA scFv to IL6. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL6. F8 fusions with IL6 revealed a preferential accumulation at the tumor site for both cytokine orientations. The IL6 can be efficiently delivered to the tumor neo-vasculature by fusion with the F8 antibody. While F8-IL6 was not as potent as other F8-based immunocytokine that exhibit similar biodistribution profiles, the fusion protein sheds light on the different roles of pro-inflammatory cytokines in boosting immunity against the tumor. This immunocytokine was designed for treating melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
scFv-IL6
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL6
Cytokines 1 Description
Interleukin 6 (IL-6) is an interleukin that acts as both a pro-inflammatory cytokine and an anti-inflammatory myokine. In humans, it is encoded by the IL6 gene.
Interleukin 6 is secreted by T cells and macrophages to stimulate immune response, e.g. during infection and after trauma, especially burns or other tissue damage leading to inflammation. IL-6 also plays a role in fighting infection, as IL-6 has been shown in mice to be required for resistance against bacterium Streptococcus pneumoniae.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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