Products

Anti-EDA Immunocytokine, scFv (F8)-IL7 (ACFP-SH110)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDA scFv to IL7. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDA as well as the biological activity of IL7. We generated and characterized novel antibody-cytokine fusion proteins ("immunocytokine") based on murine interleukin-7 (IL7), an immunomodulatory protein which has previously shown anti-cancer activity in preclinical models and whose human counterpart is currently being investigated in clinical trials. This immunocytokine was designed for treating melanoma, lung adenocarcinoma, neoplastic or inflammatory disease.      

Specifications
Target
EDA
Molecule Class
scFv-IL7
Species Reactivity
Human
Host
Human
Expression Host
CHO
Clone
F8
Related Disease
Melanoma, Lung adenocarcinoma, Neoplastic or Inflammatory disease
Cytokines 1
IL7
Cytokines 1 Description
Interleukin 7 (IL-7) is a protein that in humans is encoded by the IL7 gene. IL-7 is a hematopoietic growth factor secreted by stromal cells in the bone marrow and thymus. It is also produced by keratinocytes, dendritic cells, hepatocytes, neurons, and epithelial cells but is not produced by normal lymphocytes.
Cytokine 1 Species
Mouse
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
EDA; ectodysplasin A; ectodermal dysplasia 1; anhidrotic; ED1; EDA2; ODT1; oligodontia 1
Entrez Gene ID
1896
UniProt ID
Q92838

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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