Anti-EDB Antibody-Cytokine Fusion Protein, IgG (AS1409)-scIL12 (CAT#: ACFP-SH014)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of scIL12. Antitumor activity of this fusion protein involved a combination of T and NK cell activity, a switch to a Th1 immune response, and an anti-angiogenic activity. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • EDB
  • Molecule Class
  • IgG3-scIL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • AS1409
  • Related Disease
  • HER-2/neu over-expressing cancer
  • Cytokine 1
  • scIL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Human
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Related Resources

  • Related Diseases

Downloads

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Recombinant Antibody

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) ELISA, In vivo imaging Camelid VHH

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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