Products

Anti-EDB Immunocytokine, IgG (AS1409)-scIL12 (ACFP-SH014)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to scIL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of scIL12. Antitumor activity of this fusion protein involved a combination of T and NK cell activity, a switch to a Th1 immune response, and an anti-angiogenic activity. This immunocytokine was designed for treating HER-2/neu over-expressing cancer.      

Specifications
Target
EDB
Molecule Class
IgG3-scIL12
Species Reactivity
Human
Host
Humanized from Mouse
Expression Host
CHO
Clone
AS1409
Related Disease
HER-2/neu over-expressing cancer
Cytokines 1
scIL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS
Entrez Gene ID
2335
UniProt ID
P02751

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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