Anti-EDB Antibody-Cytokine Fusion Protein, IgG (HuBC1)-IL12 (CAT#: ACFP-SH086)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to the N-terminus of the IL12 p35 subunit, which in turn is disulfide-bonded to the p40 subunit.. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. This protein has been shown to have a longer serum half-life than huBC1-muIL12 in mice, and retains both antigen binding and IL12 activity in in vitro assays. This molecule also was found to have surprisingly low toxicity in immunocompetent mice. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.


Specific Inquiry
  • Size:
  • Conjugation:
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
RNA Expression

Specifications

  • Target
  • EDB
  • Molecule Class
  • IgG1-IL12
  • Species Reactivity
  • Human
  • Expression Host
  • CHO
  • Clone
  • HuBC1
  • Related Disease
  • Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
  • Cytokine 1
  • IL12
  • Cytokines 1 Description
  • Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
  • Cytokine 1 Species
  • Mouse
  • Applications
  • This product can be used therapeutically to deliver biologically active ligands to a desired tissue.

Target

  • Alternative Names
  • FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS; GFND2

Related Resources

  • Related Diseases

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "Clone HuBC1"

See other products for "FN1"

Human Antibody

CAT Product Name Application Type
TAB-193 Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) IF, IP, Neut, FuncS, ELISA, FC, ICC [(scFv - heavy - kappa) - IGHE - CH4]2
TAB-001CQ Anti-Human FN1 Recombinant Antibody (MOR03255) ELISA, Block, IHC Human antibody
TAB-002CQ Anti-Human FN1 Recombinant Antibody (ME-4C) ELISA, IHC Human antibody
TAB-003CQ Anti-Human FN1 Recombinant Antibody (1C5) ELISA, WB Human antibody
TAB-004CQ Human Anti-FN1 Recombinant Antibody (TAB-004CQ) ELISA, IHC, WB Human IgG

Recombinant Antibody

CAT Product Name Application Type
MOB-1294z Mouse Anti-FN1 Recombinant Antibody (clone 6H4) IHC, IP, WB Mouse IgG2b, κ
ZG-0815F Mouse Anti-FN1 Recombinant Antibody (clone EP5) IHC Mouse IgG1
ZG-0087U Rabbit Anti-FN1 Recombinant Antibody (clone 1E1) ELISA, IHC Rabbit IgG
VS3-QX434 Mouse Anti-FN1 Recombinant Antibody (clone 2F4) WB, IHC, ICC, FC, ELISA Mouse IgG1
VS-0623-WK13 Human Anti-FN1 Recombinant Antibody (clone Fn52) ELISA, WB, FuncS, RPE Cell Migration Assay, Fibronectin Assembly Assay, MMP Activity Assay Human IgG

Blocking Antibody

CAT Product Name Application Type
NEUT-852CQ Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) ELISA, WB, IP, Block Mouse IgG1
NEUT-853CQ Mouse Anti-FN1 Recombinant Antibody (clone IST-9) WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P Mouse IgG1

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-1326 Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) IHC-Fr, IHC-P, IHC-P, IP, WB Rabbit IgG

Single-domain Antibody

CAT Product Name Application Type
NBD-0040-YJ-VHH Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) ELISA, In vivo imaging Camelid VHH

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ACFP-SH086. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart

    Go to compare