This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to the N-terminus of the IL12 p35 subunit, which in turn is disulfide-bonded to the p40 subunit.. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. This protein has been shown to have a longer serum half-life than huBC1-muIL12 in mice, and retains both antigen binding and IL12 activity in in vitro assays. This molecule also was found to have surprisingly low toxicity in immunocompetent mice. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-193 | Anti-Human Fibronectin Extra Domain-B Recombinant Antibody (Radretumab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | [(scFv - heavy - kappa) - IGHE - CH4]2 |
TAB-001CQ | Anti-Human FN1 Recombinant Antibody (MOR03255) | ELISA, Block, IHC | Human antibody |
TAB-002CQ | Anti-Human FN1 Recombinant Antibody (ME-4C) | ELISA, IHC | Human antibody |
TAB-003CQ | Anti-Human FN1 Recombinant Antibody (1C5) | ELISA, WB | Human antibody |
TAB-004CQ | Human Anti-FN1 Recombinant Antibody (TAB-004CQ) | ELISA, IHC, WB | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1294z | Mouse Anti-FN1 Recombinant Antibody (clone 6H4) | IHC, IP, WB | Mouse IgG2b, κ |
ZG-0815F | Mouse Anti-FN1 Recombinant Antibody (clone EP5) | IHC | Mouse IgG1 |
ZG-0087U | Rabbit Anti-FN1 Recombinant Antibody (clone 1E1) | ELISA, IHC | Rabbit IgG |
VS3-QX434 | Mouse Anti-FN1 Recombinant Antibody (clone 2F4) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
VS-0623-WK13 | Human Anti-FN1 Recombinant Antibody (clone Fn52) | ELISA, WB, FuncS, RPE Cell Migration Assay, Fibronectin Assembly Assay, MMP Activity Assay | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0193-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0193-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0194-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0194-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0195-CN-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0195-CN-S(P)) | ELISA, FC, IHC | Human scFv |
HPAB-0196-CN-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0196-CN-S(P)) | ELISA, FC, IHC | Human scFv |
HPAB-S0038-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment | ELISA, IF, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
HPAB-1111-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1111-FY-S(P)) | IHC | Human scFv |
HPAB-1112-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1112-FY-S(P)) | IHC | Human scFv |
HPAB-1113-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1113-FY-S(P)) | IHC | Human scFv |
HPAB-1114-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1114-FY-S(P)) | IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) | ELISA, In vivo imaging | Camelid VHH |
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