Products

Anti-EDB Immunocytokine, IgG (HuBC1)-IL12 (ACFP-SH087)

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB IgG to IL12. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of IL12. It was found that huBC1-huIL12 has a longer serum half-life than huBC1-muIL12 in mice. HuBC1-huIL12 is a molecule designed to target tumor vasculature and evoke a localized immune cascade. HuBC1-(IL12) demonstrated 10-fold lower IL12 activity compared with rmIL12 as determined by the level of IFN-γ secreted by PBMC. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.      

Specifications
Target
EDB
Molecule Class
IgG1-IL12
Species Reactivity
Human
Host
Humanized from Mouse
Expression Host
CHO
Clone
HuBC1
Related Disease
Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma
Cytokines 1
IL12
Cytokines 1 Description
Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages, neutrophils, and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer (referred to as 'p70'), and a homodimer of p40 are formed following protein synthesis.
Cytokine 1 Species
Human
Applications
This product can be used therapeutically to deliver biologically active ligands to a desired tissue.
Target
Alternative Names
FN; CIG; FNZ; MSF; ED-B; FINC; GFND; LETS
Entrez Gene ID
2335
UniProt ID
P02751

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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