This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EDB scFv to GM-CSF. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EDB as well as the biological activity of GM-CSF. Biodistribution studies revealed that the GM-CSF moiety influences the pharmacokinetic properties. A depletion study showed that the antitumor effects were mainly executed by CD8+ tumor cells. This immunocytokine was designed for treating Advanced solid tumors, Advanced pancreatic cancer, Metastatic melanoma.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-071WM | Anti-Human FN1 Recombinant Antibody (CGS-1) | ELISA, WB | Human Antibody |
TAB-071WM-S(P) | Anti-Human FN1 Recombinant Antibody scFv Fragment (CGS-1) | ELISA, WB | Human Antibody |
TAB-001CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (MOR03255) | ELISA, BL, IHC | Human antibody |
TAB-002CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (ME-4C) | ELISA, IHC | Human antibody |
TAB-003CQ-F(E) | Anti-Human FN1 Recombinant Antibody Fab Fragment (1C5) | ELISA, WB | Human antibody |
CAT | Product Name | Application | Type |
---|---|---|---|
NEUT-852CQ | Mouse Anti-FN1 Recombinant Antibody (clone HFN7.1) | ELISA, WB, IP, Block | Mouse IgG1 |
NEUT-853CQ | Mouse Anti-FN1 Recombinant Antibody (clone IST-9) | WB, RIA, ELISA, IHC-Fr, ICC, IF, Block, IHC-P | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MOR-1326 | Hi-Affi™ Rabbit Anti-FN1 Recombinant Antibody (clone DS1326AB) | IHC-Fr, IHC-P, IHC-P, IP, WB | Rabbit IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0193-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0193-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
HPAB-0194-CN-S(P) | Mouse Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-0194-CN-S(P)) | ELISA, FC, IHC | Mouse scFv |
FAMAB-0105-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone ME4C); scFv Fragment | ELISA, IHC | Human scFv |
HPAB-S0037-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone CGS-2); scFv Fragment | ELISA, IB, IHC | Human scFv |
HPAB-S0038-YC-S(P) | Human Anti-FN1 Recombinant Antibody (clone L19); scFv Fragment | ELISA, IF, IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0193-CN-F(E) | Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0193-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
HPAB-0194-CN-F(E) | Mouse Anti-FN1 Recombinant Antibody; Fab Fragment (HPAB-0194-CN-F(E)) | ELISA, FC, IHC | Mouse Fab |
FAMAB-0105-YC-F(E) | Human Anti-FN1 Recombinant Antibody (clone ME4C); Fab Fragment | ELISA, IHC | Human Fab |
HPAB-1110-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1110-FY-S(P)) | IHC | Human scFv |
HPAB-1111-FY-S(P) | Human Anti-FN1 Recombinant Antibody; scFv Fragment (HPAB-1111-FY-S(P)) | IHC | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
NBD-0040-YJ-VHH | Camelid Anti-FN1 Recombinant Single Domain Antibody (NJB2) | ELISA, In vivo imaging | Camelid VHH |
CAT | Product Name | Application | Type |
---|---|---|---|
ZG-0661F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0661F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
ZG-0662F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0662F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
ZG-0663F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0663F) | IF, IHC-P, ELISA, RIA | Rabbit IgG |
ZG-0664F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0664F) | IHC-P, IF, ELISA, RIA, WB | Rabbit IgG |
ZG-0665F | Rabbit Anti-FN1 Recombinant Antibody (ZG-0665F) | IHC-P, IF, ELISA, RIA, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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